Compton-camera-based radiopharmaceutical imaging with an attenuation-corrected LM-MLEM reconstruction strategy

IF 1.6 3区物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY

Radiation Measurements Pub Date : 2025-02-01 DOI:10.1016/j.radmeas.2025.107379

Yuan Ren , Changran Geng , Xue Yang , Lijun Tang , Feng Tian , Xiaobin Tang

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引用次数: 0

Abstract

Compton cameras have garnered attention in nuclear medicine due to their broad energy detection range and high efficiency, showing potential for imaging of various therapeutic and diagnostic isotopes and theranostics. However, a current limitation on the application of Compton cameras in nuclear medical imaging is the lack of a suitable method for correcting human tissue attenuation. This research aims to propose a precise system matrix probability model that explicitly considers the attenuation effect for correcting tissue attenuation in Compton imaging of radionuclides. The model calculates the probability of tissue attenuation between imaging space pixels and detector positions and is integrated into the calculation of the system matrix and sensitivity matrix within the list-mode maximum likelihood expectation maximization (LM-MLEM) algorithm. To validate this attenuation-corrected LM-MLEM (AC-LM-MLEM) algorithm, phantom studies were conducted using both GEANT4 simulations and experiments with [¹⁸F]FDG radiopharmaceutical and a 3D-CZT Compton camera, along with animal experiments on a Sprague Dawley rat. In the simulated imaging results on the phantom model, the AC-LM-MLEM algorithm closely match the prescribed spherical source activity distribution. In the imaging results of experiments, the highly radioactive areas reconstructed by the AC-LM-MLEM algorithm are largely consistent with the clinically used positron emission tomography/computed tomography (PET/CT) reconstruction results. Qualitative and quantitative analyses of the reconstruction results indicate that the proposed AC-LM-MLEM algorithm corrects effectively for tissue attenuation.

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来源期刊

Radiation Measurements 工程技术-核科学技术

CiteScore

4.10

自引率

20.00%

发文量

116

审稿时长

48 days

期刊介绍： The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.