Pediatric pancreatic perineurioma: A case report

Abstract

Introduction

Perineuriomas are rare, benign, peripheral nerve sheath tumors that are distinguished from other lesions such as neurofibroma with specific immunohistochemical stains.

Case presentation

The patient was an 18-year-old female with a history of spina bifida and neuroblastoma. She was asymptomatic but at a follow up visit for urinary issues related to her spina bifida, an ultrasound of the kidneys revealed a retroperitoneal mass near the left kidney. Cross sectional imaging was completed and identified a left paraspinous mass measuring 13.3 x 10.1 × 11.2 cm, arising from the pancreas. Laboratory evaluations including liver function tests, complete blood count, renal panel, urine metanephrines, alpha fetoprotein and beta-hCg were normal. Complete resection of the mass required a distal pancreatectomy and splenectomy performed via laparotomy. Histologic evaluation of the mass was consistent with perineurioma. Postoperative recovery was unremarkable and the patient remains free of disease at one year followup with ultrasound imaging.

Conclusion

Perineurioma, a rare peripheral nerve sheath neoplasm, should be considered in the differential diagnosis for retroperitoneal masses in the pediatric population.