Exploring the wound healing potential of biocompatible nano-hydroxyapatite derived from parrotfish scale (Scarrus ghobban) waste for bone tissue engineering

IF 3.4 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biocatalysis and agricultural biotechnology Pub Date : 2025-02-01 DOI:10.1016/j.bcab.2025.103493

Surya Parthasarathy , Palanisamy Arulselvan , Radha Gosala , Balakumar Subramanian

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引用次数: 0

Abstract

Fish waste management and the development of sustainable applications for fish byproducts have gained significant importance in recent times. This study focuses on repurposing discarded fish scales from Scarus ghobban to synthesize nano-hydroxyapatite (n-HAp) using an alkaline hydrolysis method. The n-HAp was comprehensively characterized through various analytical techniques, including FESEM, FT-IR, XRD, and TEM. The results revealed the successful production of n-HAp particles with an average size of 20–50 nm and the presence of functional groups such as esters, ethers, halogen compounds, and nitriles along with secondary amines, phenols, and alcohols which contribute to enhanced material characteristics. Additionally, through elemental mapping minerals such as Calcium, Phosphorous, Magnesium, and Sodium were confirmed. Cytotoxicity tests using L929 fibroblast cells demonstrated biocompatibility and wound healing assays indicated its potential for tissue regeneration. This approach not only harnesses valuable resources from fish waste but also holds promise for various biomedical applications, contributing to both economic growth and environmental sustainability. Ultimately, this nano-hydroxyapatite derived from fish scales showcases remarkable biocompatibility, positioning it as a promising candidate for the development of wound dressings.

查看原文本刊更多论文

探索从鹦嘴鱼鳞（Scarrus ghobban）废物中提取的生物相容性纳米羟基磷灰石在骨组织工程中的伤口愈合潜力

近年来，鱼类废物管理和鱼类副产品可持续应用的发展具有重要意义。本研究主要研究了用碱水解法制备纳米羟基磷灰石（n-HAp）。通过FESEM、FT-IR、XRD、TEM等多种分析技术对n-HAp进行了全面表征。结果表明，成功地生产了平均尺寸为20-50 nm的n-HAp颗粒，并且存在酯、醚、卤素化合物、腈以及仲胺、酚和醇等官能团，这些官能团有助于增强材料的特性。此外，通过元素测绘，确定了钙、磷、镁和钠等矿物质。使用L929成纤维细胞进行的细胞毒性试验表明其具有生物相容性，伤口愈合试验表明其具有组织再生的潜力。这种方法不仅利用了鱼类废物中的宝贵资源，而且有望用于各种生物医学应用，有助于经济增长和环境可持续性。最终，这种从鱼鳞中提取的纳米羟基磷灰石显示出卓越的生物相容性，使其成为开发伤口敷料的有希望的候选材料。

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来源期刊

Biocatalysis and agricultural biotechnology Agricultural and Biological Sciences-Agronomy and Crop Science

CiteScore

7.70

自引率

2.50%

发文量

308

审稿时长

48 days

期刊介绍： Biocatalysis and Agricultural Biotechnology is the official journal of the International Society of Biocatalysis and Agricultural Biotechnology (ISBAB). The journal publishes high quality articles especially in the science and technology of biocatalysis, bioprocesses, agricultural biotechnology, biomedical biotechnology, and, if appropriate, from other related areas of biotechnology. The journal will publish peer-reviewed basic and applied research papers, authoritative reviews, and feature articles. The scope of the journal encompasses the research, industrial, and commercial aspects of biotechnology, including the areas of: biocatalysis; bioprocesses; food and agriculture; genetic engineering; molecular biology; healthcare and pharmaceuticals; biofuels; genomics; nanotechnology; environment and biodiversity; and bioremediation.