Design and analysis of interconnected multichannel Schottky FinFET for the detection of breast cancer cells

Abstract

This study investigates the application of dielectrically controlled Interconnected Multichannel Schottky FinFET (IC–S-FinFET) biosensor for the detection of healthy (MCF-10A) and cancerous cell lines of Hs578T, MDA-MB-231, MCF-7, and T47D. Here, the identification of distinct breast malignant cell types is established based on the variability in the dielectric constant. The evaluation of the biosensor sensitivity has been conducted for parameters such as drain current, subthreshold swing, and I_ON/I_OFF characteristics. Also, the sensitivity of both the positively (5 × 10¹¹Ccm⁻²) and negatively (−5 x 10¹¹Ccm⁻²) charged biomolecules are evaluated for different breast cancer cell lines. In addition to that, the effect of the fill factor on the nanogap was examined for neutral-charged biomolecules. It is found that the sensitivity (S_n) of the designed biosensor device is improved for the rise in fill factor from partly filled to filled nanocavity. The linearity and noise characteristics of the biosensor are also examined. These findings suggest that IC-S-FinFET holds significant potential as a novel, label-free diagnostic tool for early and accurate detection of breast cancer, contributing to improved patient outcomes through timely and precise medical interventions.