Cyclic peptides from cyanobacteria: Structural insights, biological functions, and mechanisms of cyclization

IF 4.6 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Algal Research-Biomass Biofuels and Bioproducts Pub Date : 2025-01-21 DOI:10.1016/j.algal.2025.103925

Nuo Chen , Rui Huang , Hangzhen Lan , Jouni Jokela , Huamao Wei , Shuai Zhi , Liwei Liu

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引用次数: 0

Abstract

Cyclic peptides are highly interested in natural product research due to their unique chemical structures and diverse biological activities, which substantially contribute to drug development. Cyanobacteria are recognized as a prolific source of bioactive compounds and have contributed significantly to this field. Over the past decade, 142 novel cyanobacterial cyclic peptides and peptolides from cyanobacteria have been identified, revealing many novel chemicals. Recent advancements have provided new perspectives on the cyanobacteria cyclic peptides and peptolides. This review systematically elaborates on the latest research progress, summarizing the identified cyclic peptide and peptolide structures, biological activities, and cyclization mechanisms over the past decade (2014–2023). By providing critical insights, this review aims to facilitate the discovery of novel cyclic peptides and peptolides from cyanobacteria and guide future efforts in structural engineering.

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来源期刊

Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

9.40

自引率

7.80%

发文量

332

期刊介绍： Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment