Synthesis and evaluation of novel sulfamethoxazole-containing 1,8-dioxo-decahydroacridine derivatives: Antimicrobial activity and emission properties

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2024-09-02 DOI:10.1080/10426507.2024.2402722

Fereshteh Khorasani , Mohammad Reza Islami , Hojatollah Khabazzadeh , Moj Khaleghi

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Abstract

A straightforward and efficient method for synthesizing 1,8-dioxo-decahydroacridine derivatives is presented, utilizing a one-pot, three-component condensation reaction involving dimedone, sulfamethoxazole, and aromatic aldehydes. The primary objective of this synthesis is to incorporate the sulfamethoxazole ring into the acridine family structure and examine the antibacterial effects and fluorescence properties of the compounds. The antibacterial activity of the synthesized compounds was evaluated against various gram-positive and gram-negative microorganisms, as well as a fungal strain, using the disk diffusion method, minimum inhibitory concentration determination, and bactericidal assays. Notably, five compounds exhibited potent antibacterial activity against both strains of Bacillus cereus. Furthermore, the influence of pH on the fluorescence emission intensity and absorption spectrum of the synthesized compounds was investigated, revealing that all products displayed fluorescence radiation.

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新型磺胺甲恶唑- 1,8-二氧基十氢吖啶衍生物的合成与评价：抗菌活性和发射特性

提出了一种简单有效的合成1,8-二氧基十氢吖啶衍生物的方法，利用一锅三组分缩合反应，涉及二美酮、磺胺甲恶唑和芳香醛。本合成的主要目的是将磺胺甲恶唑环纳入吖啶族结构，并研究化合物的抗菌作用和荧光性质。采用圆盘扩散法、最小抑菌浓度测定和杀菌试验，对合成的化合物对多种革兰氏阳性和革兰氏阴性微生物以及一种真菌菌株的抑菌活性进行了评价。值得注意的是，五种化合物对蜡样芽孢杆菌的两种菌株均表现出较强的抗菌活性。此外，研究了pH对合成化合物的荧光发射强度和吸收光谱的影响，发现所有产物都显示荧光辐射。

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.