Anti-corrosion and cytotoxicity properties of inorganic surface treatments on Mg1Ca biodegradable alloy

IF 5.3 2区材料科学 Q1 MATERIALS SCIENCE, COATINGS & FILMS

Surface & Coatings Technology Pub Date : 2025-02-01 DOI:10.1016/j.surfcoat.2024.131704

C.S. Neves , I. Sousa , M.A. Freitas , L. Moreira , C. Costa , J.P. Teixeira , S. Fraga , R.M. Silva , R.F. Silva , M. Starykevich , N. Scharnagl , M.L. Zheludkevich , M.G.S. Ferreira , J. Tedim

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引用次数: 0

Abstract

In this work biodegradable Mg1Ca alloy underwent surface modification using hydroxyapatite (HAp), aluminium oxide (Al₂O₃), and treatments with phosphoric (H₃PO₄), hydrofluoric (HF), and acetic (CH₃COOH) acids. The resulting surface-treated Mg substrates were assessed in terms of phase content and chemical composition through X-ray diffraction (XRD) and glow discharge optical emission spectrometry (GDOES). Additionally, atomic force microscopy (AFM) and scanning electron microscopy (SEM) were employed to examine the surface's topography and structure, while the corrosion behavior and cytotoxicity were surveyed using electrochemical impedance spectroscopy (EIS), alongside WST-1 reduction and lactate dehydrogenase (LDH) release assays on L929 mouse fibroblasts. The findings indicated that the surfaces of all samples were uniformly structured, while chemical analysis of the treated surfaces suggested the presence of mostly thin films. Furthermore, EIS results highlighted that the HAp-treated Mg1Ca alloy exhibited superior corrosion resistance, and the cytotoxicity assessment of Mg1Ca-HAp and Mg1Ca-H₃PO₄ alloys showed minimal cytotoxic effects on mouse fibroblasts, compared to other treated surfaces, suggesting enhanced biocompatibility of those two surface treatments. Overall, this constitutes the first comparative study of different surface treatments developed on biodegradable Mg1Ca alloy, aiming to identify optimal modification strategies for biomedical applications.

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来源期刊

Surface & Coatings Technology 工程技术-材料科学：膜

CiteScore

10.00

自引率

11.10%

发文量

921

审稿时长

19 days

期刊介绍： Surface and Coatings Technology is an international archival journal publishing scientific papers on significant developments in surface and interface engineering to modify and improve the surface properties of materials for protection in demanding contact conditions or aggressive environments, or for enhanced functional performance. Contributions range from original scientific articles concerned with fundamental and applied aspects of research or direct applications of metallic, inorganic, organic and composite coatings, to invited reviews of current technology in specific areas. Papers submitted to this journal are expected to be in line with the following aspects in processes, and properties/performance: A. Processes: Physical and chemical vapour deposition techniques, thermal and plasma spraying, surface modification by directed energy techniques such as ion, electron and laser beams, thermo-chemical treatment, wet chemical and electrochemical processes such as plating, sol-gel coating, anodization, plasma electrolytic oxidation, etc., but excluding painting. B. Properties/performance: friction performance, wear resistance (e.g., abrasion, erosion, fretting, etc), corrosion and oxidation resistance, thermal protection, diffusion resistance, hydrophilicity/hydrophobicity, and properties relevant to smart materials behaviour and enhanced multifunctional performance for environmental, energy and medical applications, but excluding device aspects.