Maltose-functionalized MAPbBr3 fluorescent perovskite quantum dots with strong water resistance for detection of γ-aminobutyric acid as a neurological biomarker

IF 4.1 3区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-01-20 DOI:10.1016/j.jphotochem.2025.116282

Suresh Kumar Kailasa , Mayurkumar Revabhai Patel , Madhura Pradeep Deshpande , Eunji Shin , Yoojin Choi , Tae Jung Park

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引用次数: 0

Abstract

Zero-dimensional perovskite nanostructures have always been shown outstanding applications in recognizing gases and molecular species. Herein, maltose (Malt) was introduced as an encapsulating agent for the synthesis of MAPbBr₃ fluorescent perovskite quantum dots (Malt@MAPbBr₃ PQDs), showing strong water resistance and good quantum yield (QY). The as-synthesized Malt@MAPbBr₃ PQDs have an average size of 7.25 ± 2.63 nm. The structure and elemental composition of Malt@MAPbBr₃ PQDs are confirmed by various analytical techniques. The as-synthesized Malt@MAPbBr₃ PQDs display remarkable fluorescence characteristics (λ_Ex/Em = 430/535 nm) with QY of 23.74 %. The selectivity of various biomarkers (epinephrine, normetanephrine, creatinine, dehydroepiandrosterone, uric acid, bilirubin, methyl nicotinate, γ-aminobutyric acid (GABA), Se-methylselenocystiene, and cortisone) on the fluorescence quenching of Malt@MAPbBr₃ PQDs was studied through fluorescence emission spectroscopy. Interestingly, Malt@MAPbBr₃ PQDs exhibit a noticeable fluorescence quenching (>90 %) with the limit of detection (8.37 nM) in the presence of GABA. The developed Malt@MAPbBr₃ PQDs-based fluorescent sensor is successfully applied to detect GABA in biofluids.

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来源期刊

Journal of Photochemistry and Photobiology A-chemistry 化学-物理化学

CiteScore

7.90

自引率

7.00%

发文量

580

审稿时长

48 days

期刊介绍： JPPA publishes the results of fundamental studies on all aspects of chemical phenomena induced by interactions between light and molecules/matter of all kinds. All systems capable of being described at the molecular or integrated multimolecular level are appropriate for the journal. This includes all molecular chemical species as well as biomolecular, supramolecular, polymer and other macromolecular systems, as well as solid state photochemistry. In addition, the journal publishes studies of semiconductor and other photoactive organic and inorganic materials, photocatalysis (organic, inorganic, supramolecular and superconductor). The scope includes condensed and gas phase photochemistry, as well as synchrotron radiation chemistry. A broad range of processes and techniques in photochemistry are covered such as light induced energy, electron and proton transfer; nonlinear photochemical behavior; mechanistic investigation of photochemical reactions and identification of the products of photochemical reactions; quantum yield determinations and measurements of rate constants for primary and secondary photochemical processes; steady-state and time-resolved emission, ultrafast spectroscopic methods, single molecule spectroscopy, time resolved X-ray diffraction, luminescence microscopy, and scattering spectroscopy applied to photochemistry. Papers in emerging and applied areas such as luminescent sensors, electroluminescence, solar energy conversion, atmospheric photochemistry, environmental remediation, and related photocatalytic chemistry are also welcome.