An efficient and sustainable multicomponent synthesis of structurally diverse tetrahydrochromeno[2,3-c]pyrazol-5(1H)-one using indium triflate as a reusable catalyst

Abstract

The effective and environmentally friendly synthetic approach has been presented for the synthesis of structurally diverse tetrahydrochromeno[2,3-c]pyrazol-5(1H)-one using indium triflate catalyzed the four-component reaction of aromatic aldehyde, 1,3-diketone, Phenylhydrazine and ethyl acetoacetate in solvent ethanol. The synthetic methodology has specific features such as atom and step economy, operational simplicity and excellent catalytic activity with sustainability, recyclability and reusability, resulting in structurally varied hybrid molecules with a unique combination of preferred substructures. The synthetic method of preparation of structurally diverse drug-like molecules has exceptional synthetic efficiency and molecular complexity in a shorter reaction time (15–20 min) and high product yield (85–95 %) at moderate temperatures, which contribute significantly to drug discovery research in medicinal and pharmaceutical chemistry.