Potential role of intravenous lidocaine versus intravenous ketamine for pain management in fibromyalgia patients

Q2 Nursing

Perioperative Care and Operating Room Management Pub Date : 2025-01-06 DOI:10.1016/j.pcorm.2025.100462

Maha Sadek El Derh , Sherif Essam Shabaan , Sally Saber AbdelAziz , Reham M. Hashim

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引用次数: 0

Abstract

Introduction

Fibromyalgia syndrome (FMS) is a disease characterized by chronic, pain associated with impaired physical function and overall quality of life (QOL). Pain can be controlled by IV lidocaine which is considered a topical anesthetic drug. Also, ketamine is used as a potent anesthetic agent reducing the induction of synaptic plasticity and maintenance of chronic pain states.

This study aimed

to assess the efficacy of intravenous (IV) lidocaine versus IV ketamine in pain management and improvement in the QOL in FM patients.

Patients &methods

75 patients were divided equally into 3 groups in which group A received 5 mg/Kg lidocaine, group B received 0.5 mg/Kg ketamine sulphate and group C received a placebo of normal saline. This procedure was done weekly for 3 weeks.

Result

As regards pain perception using VAS group A&B showed a marked reduction in VAS with no difference between them, with no change in group C. Changes in the fibromyalgia impact questionnaire (FIQ) were analyzed and showed the mental part of the health score decreased significantly in all groups while the physical and overall parts of the health score decreased significantly only in the lidocaine and ketamine group and non-significantly changed in the placebo group. Overall QOL significantly improved in groups A&B assessed by Health-related quality of life (HrQOL) SF-12 questionnaire 4 weeks post-procedure.

Conclusion

IV lidocaine and ketamine are efficient not only in pain relief among patients with FM but also in improving physical function and QOL.

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来源期刊

Perioperative Care and Operating Room Management Nursing-Medical and Surgical Nursing

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

56 days

期刊介绍： The objective of this new online journal is to serve as a multidisciplinary, peer-reviewed source of information related to the administrative, economic, operational, safety, and quality aspects of the ambulatory and in-patient operating room and interventional procedural processes. The journal will provide high-quality information and research findings on operational and system-based approaches to ensure safe, coordinated, and high-value periprocedural care. With the current focus on value in health care it is essential that there is a venue for researchers to publish articles on quality improvement process initiatives, process flow modeling, information management, efficient design, cost improvement, use of novel technologies, and management.