Altered controllability of functional brain networks in obsessive-compulsive disorder

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychires.2025.01.052

Ya Tian , Wenqing Shi , Qiuying Tao , Huiting Yang , Huirong Guo , Baohong Wen , Zijun Liu , Jin Sun , Huafu Chen , Yong Zhang , Jingliang Cheng , Shaoqiang Han

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引用次数: 0

Abstract

Disruptions in the dynamic transitions between brain states have been implicated in cognitive, emotional, and behavioral dysregulations across various mental disorders. However, the irregularities in dynamic brain state transitions associated with obsessive-compulsive disorder (OCD) remain unclear. The present study included 99 patients with OCD and 104 matched healthy controls (HCs) to investigate alterations in dynamic brain state transitions by using network control theory. Functional controllability metrics were computed and compared between the OCD group and HCs. Additionally, abnormal functional connectivity (FC) between the brain regions with statistical differences in functional controllability and remaining brain regions were assessed. Patients with OCD exhibited significantly decreased average controllability (AC) and increased modal controllability (MC) in the right parahippocampal gyrus (PHG), compared to the HCs. Further analysis showed significantly decreased FC between the right PHG and bilateral superior temporal gyrus and occipital gyrus, left postcentral gyrus, and right cingulate gyrus in OCD patients. The results suggest aberrant brain state transitions in OCD patients, alongside widespread disruptions within the brain functional connectome. This study highlights the critical role of altered functional controllability within the right PHG in the neuropathological mechanisms of OCD, providing novel insights into the pathogenesis of OCD.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;