Gold-silver bimetallic nanoparticles conjugated to asymmetric porphyrin for photodynamic therapy against triple negative breast cancer

IF 3.3 3区物理与天体物理 Q2 OPTICS

Journal of Luminescence Pub Date : 2025-01-04 DOI:10.1016/j.jlumin.2025.121065

N. Bridged Magaela , Muthumuni Managa , Tebello Nyokong

引用次数: 0

Abstract

5, 10, 15-Tris (4-nitrophenyl)-20-hydroxylphenylporphyrin (complex 1) was synthesized and metalated with gallium chloride (complex 2). These porphyrin complexes were then conjugated to biotin decorated gold-silver bimetallic nanoparticles (B-Au-Ag) to enhance photodynamic therapy efficiency. The photophysical properties of the porphyrin complexes and their conjugates were studied, and it was observed that the presence of (B-Au-Ag) enhanced the singlet oxygen quantum yield resulting in values of 0.60 and 0.74 for 1-B-Au-Ag and 2-B-Au-Ag, respectively. It was also observed that B-Au-Ag nanoparticles are more stable resulting in higher zeta potential when compared to the porphyrin conjugates. 2-B-Au-Ag resulted with lowest cell viability of 24.67% when compared to all other photosensitizes.

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来源期刊

Journal of Luminescence 物理-光学

CiteScore

6.70

自引率

13.90%

发文量

850

审稿时长

3.8 months

期刊介绍： The purpose of the Journal of Luminescence is to provide a means of communication between scientists in different disciplines who share a common interest in the electronic excited states of molecular, ionic and covalent systems, whether crystalline, amorphous, or liquid. We invite original papers and reviews on such subjects as: exciton and polariton dynamics, dynamics of localized excited states, energy and charge transport in ordered and disordered systems, radiative and non-radiative recombination, relaxation processes, vibronic interactions in electronic excited states, photochemistry in condensed systems, excited state resonance, double resonance, spin dynamics, selective excitation spectroscopy, hole burning, coherent processes in excited states, (e.g. coherent optical transients, photon echoes, transient gratings), multiphoton processes, optical bistability, photochromism, and new techniques for the study of excited states. This list is not intended to be exhaustive. Papers in the traditional areas of optical spectroscopy (absorption, MCD, luminescence, Raman scattering) are welcome. Papers on applications (phosphors, scintillators, electro- and cathodo-luminescence, radiography, bioimaging, solar energy, energy conversion, etc.) are also welcome if they present results of scientific, rather than only technological interest. However, papers containing purely theoretical results, not related to phenomena in the excited states, as well as papers using luminescence spectroscopy to perform routine analytical chemistry or biochemistry procedures, are outside the scope of the journal. Some exceptions will be possible at the discretion of the editors.