Targeted and pH-sensitive polyzwitterionic liposomes for oral anticancer drug delivery

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology Pub Date : 2025-01-17 DOI:10.1016/j.partic.2025.01.001

Mingyang Hu , Rui Zheng , Qi Pan , Chen Peng , Xinyue Zhang , Wei He , Wenlong Yao , Yan Li

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Abstract

Compared to intravenous injection, oral administration is attractive due to its many advantages for cancer therapy. Taken physiological barriers and other profiles of oral anticancer drug carriers into consideration, targeted and pH-sensitive polyzwitterionic liposomes (ZL) based on zwitterionic poly(carboxybetaine) (PCB) were constructed for oral delivery of doxorubicin hydrochloride (DOX·HCl) for cancer therapy. The DOX-ZL with 40% trehalose had good lyophilization stability, which would be packaged into enteric capsules to enhance their stability in stomach. In addition, DOX-ZL exhibited good storage stability and serum stability. The DOX-ZL could achieve controlled release of DOX·HCl at the endosomal pH 5.0 due to the pH-sensitive of zwitterionic PCB. Importantly, DOX-ZL could targeted deliver DOX·HCl to Caco-2 cells to cross the intestinal epithelial cell layer. The empty ZL had good biocompatibility, while DOX-ZL significantly inhibited tumor cells growth due to their high cellular uptake and controlled drug release ability. Therefore, this work provided a promising approach for oral cancer therapy.

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来源期刊

Particuology 工程技术-材料科学：综合

CiteScore

6.70

自引率

2.90%

发文量

1730

审稿时长

32 days

期刊介绍： The word ‘particuology’ was coined to parallel the discipline for the science and technology of particles. Particuology is an interdisciplinary journal that publishes frontier research articles and critical reviews on the discovery, formulation and engineering of particulate materials, processes and systems. It especially welcomes contributions utilising advanced theoretical, modelling and measurement methods to enable the discovery and creation of new particulate materials, and the manufacturing of functional particulate-based products, such as sensors. Papers are handled by Thematic Editors who oversee contributions from specific subject fields. These fields are classified into: Particle Synthesis and Modification; Particle Characterization and Measurement; Granular Systems and Bulk Solids Technology; Fluidization and Particle-Fluid Systems; Aerosols; and Applications of Particle Technology. Key topics concerning the creation and processing of particulates include: -Modelling and simulation of particle formation, collective behaviour of particles and systems for particle production over a broad spectrum of length scales -Mining of experimental data for particle synthesis and surface properties to facilitate the creation of new materials and processes -Particle design and preparation including controlled response and sensing functionalities in formation, delivery systems and biological systems, etc. -Experimental and computational methods for visualization and analysis of particulate system. These topics are broadly relevant to the production of materials, pharmaceuticals and food, and to the conversion of energy resources to fuels and protection of the environment.

文献相关原料

公司名称

产品信息

索莱宝

(5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)

索莱宝

(5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)

索莱宝

(5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)

阿拉丁

DOX·HCl

阿拉丁