Effect of stimulant medications on immunity in the treatment of attention deficit hyperactivity disorder

Q4 Medicine

Psiquiatria Biologica Pub Date : 2024-11-23 DOI:10.1016/j.psiq.2024.100546

Alberto Rodríguez-Quiroga , Miriam Akasbi Montalvo , Miguel Ángel Álvarez-Mon González , Fernando Mora Mínguez , Javier Quintero Gutiérrez del Álamo

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引用次数: 0

Abstract

Background

Research suggests a potential link between attention deficit hyperactivity disorder (ADHD) and the immune system, with higher rates of allergic conditions observed in ADHD patients. Altered levels of cytokines, crucial immune signaling molecules, are also associated with ADHD, and stimulant medications may modulate immune activity.

Objective

The objective is to raise awareness of the intricate relationship between ADHD and the immune system, shedding light on its potential implications for treatment and management strategies.

Material and methods

Descriptive study of the case report type based on the case report guidelines.

Case description

A 41-year-old male with systemic lupus erythematosus (SLE) was referred for anxiety symptoms. His medical history included SLE diagnosis and chronic steroid therapy. He reported inconsistent attention, difficulty in task planning and organization, restlessness, and impulsivity. Comprehensive assessment confirmed ADHD diagnosis. He was prescribed melatonin, vortioxetine, and methylphenidate, which significantly improved his symptoms. SLE antibody levels decreased with treatment.

Conclusion

The detection of ADHD and specific treatment with stimulants not only improved his symptoms but also led to a decrease in SLE antibodies and an enhancement in quality of life for the patient.

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兴奋剂治疗注意缺陷多动障碍对免疫的影响

研究表明，注意缺陷多动障碍（ADHD）与免疫系统之间存在潜在联系，注意缺陷多动障碍患者出现过敏状况的几率更高。细胞因子水平的改变，关键的免疫信号分子，也与多动症有关，兴奋剂药物可能调节免疫活动。目的提高人们对ADHD与免疫系统之间复杂关系的认识，揭示其治疗和管理策略的潜在含义。材料与方法根据病例报告指南对病例报告类型进行描述性研究。病例描述：一位41岁男性系统性红斑狼疮（SLE）患者因焦虑症状被转诊。他的病史包括SLE诊断和慢性类固醇治疗。他报告了注意力不一致，任务计划和组织困难，烦躁不安和冲动。综合评估证实ADHD诊断。医生给他开了褪黑素、沃替西汀和哌醋甲酯，这些药物显著改善了他的症状。SLE抗体水平随治疗而降低。结论ADHD的发现和兴奋剂的特异性治疗不仅改善了患者的症状，而且降低了SLE抗体，提高了患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psiquiatria Biologica Medicine-Psychiatry and Mental Health

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.