Difference in degree centrality of brain functional connectivity between patients with treatment-resistant depression and patients with non-treatment-resistant depression compared with healthy individuals

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2025-01-24 DOI:10.1016/j.ejpsy.2025.100292

Li-Kai Cheng , Li-Fen Chen , Tung-Ping Su , Cheng-Ta Li , Wei-Chen Lin , Shih-Jen Tsai , Ya-Mei Bai , Pei-Chi Tu , Mu-Hong Chen

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引用次数: 0

Abstract

Background and objectives

Evidence suggests that treatment-resistant depression (TRD) is associated with more prominent and widespread brain alterations in areas related to mood and cognition compared with non-treatment-resistant depression (nTRD). However, direct comparisons of brain functioning between TRD and nTRD are scarce.

Methods

We applied graph theory-based resting-state functional magnetic resonance imaging analysis to compare the degree centrality (DC) of brain functional connectivity among 31 patients with TRD, 28 patients with nTRD, and 30 healthy controls. Cognitive function was assessed using working memory and go/no-go tasks.

Results

Compared with controls, patients with TRD exhibited reduced DC in the left cuneus, right frontal operculum cortex, cerebellum vermis I, II, and IX, and left cerebellum lobule X. The DC in the right cerebellum lobule III was lower in patients with TRD compared with those with nTRD. Among patients with TRD, we discovered positive associations between mean reaction time on the go/no-go task and DC in the left cuneus (r = 0.44, p = 0.015) and the right frontal operculum cortex (r = 0.41, p = 0.025). Conversely, the mean reaction time on the working memory task was inversely correlated with DC in the left cerebellar lobule X (r = −0.43, p = 0.019).

Conclusion

Our findings highlight the important roles of the cerebellum (specifically, lobule X, and the right lobule III), frontal operculum, and cuneus in TRD. Dysfunction in these brain regions, which are integral to the salience and default mode networks, is likely associated with TRD-related cognitive dysfunction.

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治疗难治性抑郁症患者与非治疗难治性抑郁症患者与健康个体相比脑功能连接度中心性的差异

背景和目的有证据表明，与非治疗抵抗性抑郁症（nTRD）相比，治疗抵抗性抑郁症（TRD）与情绪和认知相关区域的大脑改变更为突出和广泛。然而，TRD和nTRD之间大脑功能的直接比较很少。方法应用基于图论的静息状态功能磁共振成像分析，比较31例TRD患者、28例nTRD患者和30例健康对照者的脑功能连接度中心性（DC）。认知功能通过工作记忆和去/不去任务来评估。结果与对照组相比，TRD患者的左楔叶、右额盖皮层、小脑I、II、IX和左小脑x小叶DC明显减少。TRD患者的右小脑III小叶DC低于nTRD患者。在TRD患者中，我们发现走/不走任务的平均反应时间与左楔叶（r = 0.44, p = 0.015）和右额盖皮层（r = 0.41, p = 0.025）的DC呈正相关。相反，工作记忆任务的平均反应时间与左小脑X小叶DC呈负相关（r = - 0.43, p = 0.019）。结论我们的研究结果强调了小脑（特别是X小叶和右III小叶）、额盖和楔叶在TRD中的重要作用。这些脑区是突出和默认模式网络的组成部分，其功能障碍可能与trd相关的认知功能障碍有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.