Effectiveness of bright light therapy in patients suffering from unipolar or bipolar depression; A naturalistic study

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2025-01-24 DOI:10.1016/j.ejpsy.2025.100294

M.A. Riedinger , G.E. van Son , N.J.A. van der Wee , E.J. Giltay , M. de Leeuw

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引用次数: 0

Abstract

Background and objectives

Depressive disorders, both unipolar (MDD) and bipolar (BD), impact patients and society greatly. In bipolar depression and seasonal affective disorder the episodic nature and periodicity relate to changes in circadian rhythms. Bright light therapy (BLT) is thought to ameliorate symptoms of depression through its influence on circadian rhythms. Effectiveness of BLT has not been thoroughly established in real-world clinical samples.

Methods

For seventy-four patients with depression Inventory of Depressive Symptoms – Self Rated (IDS-SR) scores were available through Routine Outcome Monitoring (ROM) used in BLT in the outpatient clinic for mood disorders. Patients received one or two weeks of add-on BLT as usual care. Patients suffering from MDD (n = 33, 60.6 % female, mean age 36.1 ± 11.5 years) were compared to patients suffering from BD (n = 41, 70.7 % female, mean age 45.0 ± 14.5 years) and changes in individual symptoms were analyzed for these two groups as well as the whole cohort.

Results

IDS-SR scores decreased significantly in both groups of patients and did not differ in effect size between the groups. Explorative analyses of the effects on individual items of the IDS-SR showed that items related to core symptoms of depression such a as mood, concentration and energy level showed the largest improvements.

Conclusion

Self-report depressive symptoms in patients suffering from either MDD or BD decreased in this naturalistic cohort after receiving BLT.

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强光疗法对单极或双相抑郁症患者的疗效一个自然主义的研究

背景与目的抑郁症，包括单极抑郁症（MDD）和双相抑郁症（BD），对患者和社会的影响很大。在双相抑郁症和季节性情感障碍中，发作性和周期性与昼夜节律的变化有关。明亮的光疗法（BLT）被认为是通过影响昼夜节律来改善抑郁症的症状。在现实世界的临床样本中，BLT的有效性尚未得到彻底的证实。方法采用常规结局监测（ROM）方法对74例抑郁症患者进行抑郁症状自评量表（ims - sr）评分。患者接受了一到两周的常规治疗。将MDD患者（n = 33，女性60.6%，平均年龄36.1±11.5岁）与BD患者（n = 41，女性70.7%，平均年龄45.0±14.5岁）进行比较，分析两组及整个队列的个体症状变化。结果两组患者的sid - sr评分均显著降低，两组间效应量无差异。探索性分析表明，与抑郁核心症状相关的项目，如情绪、注意力和能量水平，改善最大。结论在接受BLT治疗后，MDD或BD患者自我报告的抑郁症状有所减轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.