PVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modified porphyrin ligands: Characterization and photodynamic action on bladder cancer cells

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-12-08 DOI:10.1016/j.dyepig.2024.112580

Nuno M.M. Moura , Melani J.A. Reis , Carlos Lodeiro , M. Graça P.M. S. Neves , José A.S. Cavaleiro , Carlos F. Ribeiro , Rosa Fernandes , Ana T.P.C. Gomes

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Abstract

Cancer stands as the second leading global cause of death, following heart disease. Considering the severe side effects revealed by some chemotherapeutics for tumor treatment and anticancer therapies, the scientific community is actively exploring more effective alternatives. Photodynamic Therapy (PDT) mediated by porphyrin-based photosensitizers (PS) has emerged as an attractive alternative to more conventional therapies. In this study, we incorporated bis-cyclometalated iridium(III) complexes featuring porphyrin-arylbipyridine ligands into poly(vinylpyrrolidone) (PVP) micelle. This integration resulted in photostable PVP-PS formulations with a remarkable capability to generate singlet oxygen. These formulations were also efficiently internalized by HT-1379 cells and due to these features, their photodynamic action against human bladder cancer cells (HT-1376 cell line) was assessed. All the formulations demonstrated high photodynamic activity, with PVP-2 and PVP-3 proving to be the most promising PS, as evidenced by their lower IC50_PDT values. It was also demonstrated that all PVP-based formulations provide a safe and effective approach for photodynamic therapy (PDT) in bladder cancer, as no cytotoxic effects were observed in Vero cells.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.