Advances in small-molecule fluorescent probes for cellular senescence diagnosis and therapy: A review

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-12-17 DOI:10.1016/j.dyepig.2024.112599

Xiao Wang, Ziwei Huang, Chunhong Sui, Mengran Xu, Xin Sun

引用次数: 0

Abstract

Cellular senescence is not only a key component of the natural aging process driven by multiple factors but is also closely linked to the development of age-related diseases such as Alzheimer's, cardiovascular diseases, and cancer. Investigating the application of small-molecule fluorescent probes for non-invasive monitoring and treatment of senescence-related diseases holds significant potential. Accurate detection of senescence biomarkers using these probes offers promising opportunities for early diagnosis. Thoughtful design of these probes with therapeutic capabilities may provide new strategies for disease intervention, potentially slowing the senescence process and addressing the challenges posed by a senescence population. In this review, we highlight recent advancements in the use of small-molecule fluorescent probes for detecting senescence biomarkers and exploring therapeutic strategies.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.