Circulating stress hormones, brain health, and cognition in healthy older adults: Cross-sectional findings and sex differences in AGE-WELL

IF 4 Q2 NEUROSCIENCES
Maxie Liebscher , Silke White , Anne Chocat , Florence Mezenge , Brigitte Landeau , Marion Delarue , Oriane Hébert , Anne-Laure Turpin , Natalie L. Marchant , Gaël Chételat , Olga Klimecki , Géraldine Poisnel , Miranka Wirth
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Abstract

Background

Increased stress is a proposed risk factor for Alzheimer’s disease (AD). We examined the cross-sectional associations between circulating stress biomarkers and multimodal measures of brain health and cognition susceptible to AD in older adults and sex-specific subgroups.

Methods

Baseline data from 132 cognitively unimpaired non-depressed participants (age=74.0±4.0 years, women: n=80) in the Age-Well trial (NCT02977819) were included. Stress hormone levels were measured in overnight fasting blood serum (cortisol, dehydroepiandrosterone sulfate (DHEAS)) and blood plasma (epinephrine, norepinephrine) samples. AD-sensitive measures of brain health, including glucose metabolism (n=89), cerebral perfusion, gray matter volume, and amyloid deposition in a priori regions of interest, and cognitive markers were evaluated. Models were adjusted for age, sex, education, trait anxiety, and depressive symptoms.

Results

Higher epinephrine was associated (pFDR<0.05) with lower glucose metabolism in the anterior cingulate cortex (ACC, β=-0.26, p=.008), posterior cingulate cortex (PCC, β=-0.32, p=.006) and precuneus (β=-0.27, p=.021) and lower perfusion in the PCC (β=-0.23, p=.013). Interactions between stress hormones and sex showed (pFDR<0.05) that in women only, higher epinephrine was associated with larger ACC volume (interaction: β=0.32, p=.016), whereas in men only, higher cortisol was associated with lower episodic memory performance (interaction: β=0.98, p=.012).

Conclusions

The present study demonstrates the involvement of circulating stress hormones, particularly epinephrine and cortisol, in higher resilience or vulnerability of brain health and cognition indicators susceptible to AD in older adults. The identification of sex-specific patterns in these associations may inform the development of more effective and tailored interventions.
循环应激激素、大脑健康和健康老年人的认知:AGE-WELL的横断面研究结果和性别差异
背景:压力增加是阿尔茨海默病(AD)的一个危险因素。我们研究了循环应激生物标志物与老年人和性别特异性亚组易患AD的大脑健康和认知的多模式测量之间的横断面关联。方法纳入年龄- well试验(NCT02977819)中132名认知功能未受损的非抑郁参与者(年龄=74.0±4.0岁,女性:n=80)的基线数据。在空腹过夜的血清(皮质醇、硫酸脱氢表雄酮(DHEAS))和血浆(肾上腺素、去甲肾上腺素)样本中测量应激激素水平。对ad敏感的脑健康指标进行评估,包括葡萄糖代谢(n=89)、脑灌注、灰质体积和先验感兴趣区域的淀粉样蛋白沉积,以及认知标志物。模型根据年龄、性别、教育程度、特质焦虑和抑郁症状进行了调整。结果高肾上腺素与前扣带皮质(ACC, β=-0.26, p= 0.008)、后扣带皮质(PCC, β=-0.32, p= 0.006)、楔前叶(β=-0.27, p= 0.021)、前扣带皮质灌流降低(β=-0.23, p= 0.013)相关(pfdr0.05)。应激激素和性别之间的相互作用显示(pFDR<0.05),仅在女性中,较高的肾上腺素与较大的ACC体积相关(相互作用:β=0.32, p= 0.016),而仅在男性中,较高的皮质醇与较低的情景记忆表现相关(相互作用:β=0.98, p= 0.012)。结论本研究表明,循环应激激素,特别是肾上腺素和皮质醇,参与老年人大脑健康和认知指标易受AD影响的高弹性或脆弱性。识别这些关联的性别特异性模式可能为制定更有效和更有针对性的干预措施提供信息。
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来源期刊
Biological psychiatry global open science
Biological psychiatry global open science Psychiatry and Mental Health
CiteScore
4.00
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审稿时长
91 days
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