Effect of a single session of transcranial pulse stimulation (TPS) on resting tremor in patients with Parkinson’s disease

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2024-12-18 DOI:10.1016/j.brainres.2024.149405

Paolo Manganotti , Marco Liccari , Tiziana Maria Isabella Lombardo , Jacopo Della Toffola , Valentina Cenacchi , Mauro Catalan , Pierpaolo Busan

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引用次数: 0

Abstract

Introduction

Tremor is a common symptom in movement disorders and is evident at rest in Parkinson’s Disease (PD). In PD, tremor may be responsive to brain stimulation, ranging from Deep Brain Stimulation to Transcranial Magnetic Stimulation. Transcranial Pulse Stimulation (TPS) is a novel/painless/non-invasive technique which appears to induce biomolecular changes through shock waves. Here, as one of the first studies in the field of PD, we exploratively investigate the possibility to observe changes in tremor, induced by single-session TPS delivered on the motor cortex of PD patients.

Methods

TPS was delivered in 16 patients. Of these, 9 were admitted to sham (placebo). Resting tremor was measured at baseline (T0), after TPS (T1), and after 24 h from intervention (T2).

Results

At baseline, tremor was always present. After TPS, tremor reduction was noted at T1 and T2 (compared to T0 and placebo). We noted a decrease in the amplitude of resting tremor (not its frequency).

Discussion

TPS is a non-invasive technique that may be a novel solution for reducing tremor in PD, lasting at least 24 h after single-sessions. No side effects were reported. We discuss evidence suggesting potential physiological changes in mechanisms of neural circuits that are affected in PD.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.