Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid

IF 3.5 Q3 Biochemistry, Genetics and Molecular Biology
Azhar H. Ali , Mohanad Yakdhan Saleh , Qusay Abdulazahra Yaqoob , Shakir M. Saied , Mohammed Sami Hasan , Khalid Ahmed Owaid , Basma A.A. Balboul , Heba.G. Abdelzaher , M.A. Abdelzaher , Alaa Muqbil Alsirhani
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Abstract

Focus of this study is on the use of the hydrazone compound (3) (N-(4-bromobenzylidene)-4-(1H-indol-3-yl) butane hydrazide), which was previously prepared from the reaction of the compound p-bromobenzaldehyde with the corresponding hydrazide (2), as an intermediate compound for the synthesis of azetidine, thiazolidine, tetrazole, oxadiazole and phthalazine heterocyclic compounds through its reaction with some cyclic reagents and catalysts such as chloro acetyl chloride, thioglycolic acid, sodium-azid, lead dioxide and Hydrogen chloride gas. The prepared compounds were characterized using physical properties and also spectroscopic methods such as infrared spectroscopy, nuclear magnetic resonance spectra of the proton and the isotope of carbon13 as well as mass spectrometry, which accurately identified the proposed structures of the prepared compounds. The identity of the prepared compounds was determined using physical and spectroscopic properties, where infrared and 1HNMR spectroscopy of the proton as well as carbon13 were used in addition to using mass spectrometry to verify the validity of the prepared structures. Conclusions: Also, the biological antibacterial evaluation of the compounds (4–8) was conducted and it gave a good result compared to the drug (8) used as a reference for the control, The MTT test was performed on the healthy and cancerous cells of the compounds (4,5,8) and gave an excellent result for the compound (8).

Abstract Image

吲哚丁酸抗菌抗癌活性的综合评价
本研究的重点是利用先前由化合物对溴苯甲醛与相应的肼(2)反应制备的腙化合物(3)(N-(4-溴苄苄基)-4-(1h -吲哚-3-基)丁烷肼)作为中间体化合物,通过与氯乙酰氯、巯基乙酸、噻唑、恶二唑、酞嗪类杂环化合物等环试剂和催化剂的反应,合成氮啶、噻唑、四唑、恶二唑、酞嗪类杂环化合物。叠氮钠,二氧化铅和氯化氢气体。利用物性、红外光谱、质子核磁共振光谱、碳13同位素以及质谱等光谱方法对所制备化合物进行了表征,准确地鉴定了所制备化合物的结构。所制备化合物的身份是通过物理和光谱性质来确定的,其中质子和碳13的红外和1HNMR光谱除了使用质谱法来验证所制备结构的有效性外,还使用了质谱法来验证所制备结构的有效性。结论:对化合物(4 - 8)进行了生物抑菌评价,与对照药物(8)相比,其抑菌效果较好;对化合物(4、5、8)的健康细胞和癌细胞进行了MTT试验,其抑菌效果较好。
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来源期刊
Journal of Genetic Engineering and Biotechnology
Journal of Genetic Engineering and Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
5.70
自引率
5.70%
发文量
159
审稿时长
16 weeks
期刊介绍: Journal of genetic engineering and biotechnology is devoted to rapid publication of full-length research papers that leads to significant contribution in advancing knowledge in genetic engineering and biotechnology and provide novel perspectives in this research area. JGEB includes all major themes related to genetic engineering and recombinant DNA. The area of interest of JGEB includes but not restricted to: •Plant genetics •Animal genetics •Bacterial enzymes •Agricultural Biotechnology, •Biochemistry, •Biophysics, •Bioinformatics, •Environmental Biotechnology, •Industrial Biotechnology, •Microbial biotechnology, •Medical Biotechnology, •Bioenergy, Biosafety, •Biosecurity, •Bioethics, •GMOS, •Genomic, •Proteomic JGEB accepts
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