Baseline shock index and baroreflex function in older adults

Aging and health research Pub Date : 2025-01-13 DOI:10.1016/j.ahr.2025.100220

Kenneth M. Madden , Boris Feldman , Graydon S. Meneilly

{"title":"Baseline shock index and baroreflex function in older adults","authors":"Kenneth M. Madden , Boris Feldman , Graydon S. Meneilly","doi":"10.1016/j.ahr.2025.100220","DOIUrl":null,"url":null,"abstract":"<div><div>Elevations in shock index (SI), defined as heart rate (HR)/systolic blood pressure (BP) are less discriminative of impending shock in older adults. We hypothesized baroreflex dysfunction as a potential explanation for lower baseline SI in older adults. 52 older adults (29 women, 23 men, age ≥ 65; mean age 77.8 ± 0.9 years) were recruited. SI, the modified shock index (MSI, HR/mean BP), and the age corrected SI (Age * SI) as well as baroreflex function (using the sequence method) was measured at baseline. SI (Standardized <strong>β</strong> = 0.392, <em>p</em> = 0.005), MSI (Standardized <strong>β</strong> = 0.385, <em>p</em> = 0.006) and Age * SI (Standardized <strong>β</strong> = 0.431, <em>p</em> = 0.002) showed significant positive associations with BRS<sub>up</sub>. Age * SI also showed a significant positive association with BRS (Standardized <strong>β</strong> = 0.329, <em>p</em> = 0.019). Autonomic dysfunction is associated with lower SI in older adults, potentially masking circulatory instability.</div><div>ClinicalTrials.gov ID <span><span>NCT01914133</span><svg><path></path></svg></span></div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100220"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and health research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667032125000010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Elevations in shock index (SI), defined as heart rate (HR)/systolic blood pressure (BP) are less discriminative of impending shock in older adults. We hypothesized baroreflex dysfunction as a potential explanation for lower baseline SI in older adults. 52 older adults (29 women, 23 men, age ≥ 65; mean age 77.8 ± 0.9 years) were recruited. SI, the modified shock index (MSI, HR/mean BP), and the age corrected SI (Age * SI) as well as baroreflex function (using the sequence method) was measured at baseline. SI (Standardized β = 0.392, p = 0.005), MSI (Standardized β = 0.385, p = 0.006) and Age * SI (Standardized β = 0.431, p = 0.002) showed significant positive associations with BRS_up. Age * SI also showed a significant positive association with BRS (Standardized β = 0.329, p = 0.019). Autonomic dysfunction is associated with lower SI in older adults, potentially masking circulatory instability.

ClinicalTrials.gov ID NCT01914133

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊