Gait changes induced by a 6-min walking exercise in individuals with myotonic dystrophy type 1: relationship with muscle strength

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-02-01 DOI:10.1016/j.clinbiomech.2025.106446

Barthélémy Hoerter , Yosra Cherni , Alain Steve Comtois , Maria Vocos , Louis-Nicolas Veilleux , Laurent Ballaz

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引用次数: 0

Abstract

Background

Myotonic dystrophy type 1 is an inherited muscular dystrophy characterized by muscle weakness, myotonia, and balance deficits, contributing to early fatigue and increased risk of fall during walking. This study investigated gait changes due to continuous walking exercise.

Methods

Fourteen individuals with myotonic dystrophy type 1 were included (age 42.0 ± 8.8 years, height 1.63 ± 0.10 m, mass 75.2 ± 22.2 kg). Maximal isometric hip and knee strength was measured using a handheld dynamometer. A 3D gait analysis, using a 12-camera optoelectronic system, was performed during a 6-min walking exercise on a quasi-oval track.

Findings

A decrease in step length (−3.4 %, P = 0.002), walking speed (−7.1 %, P = 0.002) and cadence (−3.4 %, P = 0.013) was observed following the 6-min walking exercise. Double support time increased (10.0 %, P = 0.032) and maximum base of support width increased (5.7 %, P = 0.023), while center of mass amplitude decreased (−5.3 %, P = 0.048). Hip and knee extensor strength positively correlated with step length at the beginning of the 6-min walking exercise (P = 0.010 and P = 0.022 respectively).

Interpretation

This study reveals key gait changes during a 6-min walking exercise in individuals with myotonic dystrophy type 1. Spatiotemporal changes highlight the importance of targeted interventions to manage muscle weakness and improve mobility in this population. Future studies should examine these changes over longer periods and in various conditions to better understand gait changes during typical daily activities in individuals with myotonic dystrophy type 1.

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1型肌强直性营养不良患者6分钟步行运动引起的步态变化：与肌力的关系

背景：1型肌强直性营养不良是一种以肌肉无力、肌强直和平衡缺陷为特征的遗传性肌肉营养不良，可导致早期疲劳和行走时跌倒的风险增加。本研究调查了连续步行运动引起的步态变化。方法：纳入14例1型强直性肌营养不良患者（年龄42.0±8.8岁，身高1.63±0.10 m，体重75.2±22.2 kg）。使用手持式测力仪测量髋关节和膝关节的最大等距力量。在准椭圆形轨道上进行6分钟的步行运动时，使用12个摄像头光电系统进行3D步态分析。结果：6分钟步行运动后，步长（- 3.4%,P = 0.002）、步行速度（- 7.1%,P = 0.002）和步频（- 3.4%,P = 0.013）均下降。双支撑时间增加（10.0%,P = 0.032），最大支撑宽度增加（5.7%,P = 0.023），质心振幅减小（- 5.3%,P = 0.048）。在6 min步行运动开始时，髋关节和膝关节伸肌力量与步长呈正相关（P = 0.010和P = 0.022）。解释：本研究揭示了1型肌强直性营养不良患者在6分钟步行运动中关键的步态变化。时空变化突出了有针对性的干预措施对控制肌肉无力和改善这一人群的活动能力的重要性。未来的研究应该在更长的时间和不同的条件下检查这些变化，以更好地了解1型肌强直性营养不良患者在典型的日常活动中的步态变化。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.