Navigating Metabolic Complexity and in-Depth Analysis of Metabolic Syndrome among Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis.

IF 1.3 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Meiwen Zhang, Bo Lou, Weiyuan Huang
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Abstract

Background: This systematic review and meta-analysis aimed to evaluate the prevalence and clinical implications of metabolic syndrome in individuals with diabetes mellitus.

Methods: A comprehensive search was conducted across multiple databases using key terms related to metabolic syndrome and diabetes. Access to subscription-based journals was facilitated through the HINARI program. Study quality was assessed using the adapted Newcastle-Ottawa scale, with a minimum inclusion score of ≥5/10. Statistical analysis included a meta-analysis using the DerSimonian and Laird random-effects model to determine the pooled prevalence, with heterogeneity assessed using Cochran's Q and I2 statistics. Publication bias was evaluated via funnel plot symmetry. Analyses were conducted using Stata/MP 17.0.

Results: The meta-analysis revealed a pooled effect size of 1.98 (95% CI: 1.85, 2.10), with significant heterogeneity (I2 = 92.35%). Prevalence ranged from 19.88% to 88.13%, underscoring a substantial burden. Variations in HbA1c, HDL cholesterol, blood pressure, and BMI highlighted the heterogeneity in metabolic syndrome characteristics. Advanced statistical approaches enriched the understanding of metabolic profiles and their interplay with glycemic control and lipid metabolism.

Conclusion: This study underscores the critical interplay between glycemic control and lipid profiles in metabolic syndrome. The findings emphasize the need for tailored, region-specific interventions to address its substantial burden and implications for clinical practice and policy.

糖尿病患者代谢复杂性导航和代谢综合征深度分析:系统综述和荟萃分析。
背景:本系统综述和荟萃分析旨在评估糖尿病患者代谢综合征的患病率和临床意义。方法:使用与代谢综合征和糖尿病相关的关键术语在多个数据库中进行全面搜索。通过HINARI计划促进了对订阅期刊的访问。采用纽卡斯尔-渥太华量表评估研究质量,最低纳入评分≥5/10。统计分析包括使用DerSimonian和Laird随机效应模型进行荟萃分析,以确定合并患病率,并使用Cochran的Q和I2统计来评估异质性。通过漏斗图对称评价发表偏倚。使用Stata/MP 17.0进行分析。结果:meta分析显示合并效应大小为1.98 (95% CI: 1.85, 2.10),异质性显著(I2 = 92.35%)。患病率为19.88%至88.13%,负担沉重。HbA1c、HDL、血压和BMI的变化突出了代谢综合征特征的异质性。先进的统计方法丰富了对代谢谱及其与血糖控制和脂质代谢的相互作用的理解。结论:本研究强调了代谢综合征中血糖控制和脂质谱之间的关键相互作用。研究结果强调需要有针对性的区域干预措施,以解决其巨大负担和对临床实践和政策的影响。
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来源期刊
Iranian Journal of Public Health
Iranian Journal of Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
2.20
自引率
7.10%
发文量
300
审稿时长
3-8 weeks
期刊介绍: Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above men­tioned research areas.
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