Histopathologic Spectrum and Clinical Management of Pharyngeal and Laryngeal Sarcomas.

IF 1.8 3区 医学 Q3 ONCOLOGY
Oncology Pub Date : 2025-02-03 DOI:10.1159/000543016
Anna K Stenzl, Carolin Mogler, Amir Bolooki, Felix Johnson, Olivia Jeleff-Wölfler, Ulrich Strassen, Benedikt G Hofauer
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引用次数: 0

Abstract

Introduction: Sarcomas are rare mesenchymal malignancies (<1% of all cancer types), with 5-15% occurring in the head and neck. Common types include osteosarcoma, chondrosarcoma, and rhabdomyosarcoma. They often recur and have poor survival rates. Treatment involves surgery, radiation, and/or chemotherapy, utilizing a multidisciplinary approach. This study aimed to overview sarcomas at our hospital and illustrated the interdisciplinary management of pharyngeal and laryngeal cases.

Methods: This single-center study provides a comprehensive analysis of head and neck sarcomas (HNS) and examines interdisciplinary treatment approaches for pharyngeal and laryngeal sarcomas in patients treated at the Department of Head and Neck Surgery, Technical University of Munich, from 2007 to 2022. The study encompasses data on age, gender, histopathological diagnoses, treatment modalities, follow-up, and outcomes, with an emphasis on histopathological findings and collaborative therapeutic strategies.

Results: Twenty-seven cases of HNS were identified (2007-2022). Among these, 11 were pharyngeal or laryngeal sarcomas. All pharyngeal sarcomas underwent primary resection with reconstruction based on tumor location and extent. In laryngeal sarcomas, 3 required laryngectomy, 1 had a hemilaryngectomy, and 1 patient opted for primary radiochemotherapy over laryngopharyngectomy. Adjuvant radiotherapy was given in 5 cases, and radiochemotherapy in 3. Diagnoses included a range of soft tissue and bone sarcomas, such as liposarcoma, synovial sarcoma, and osteosarcoma. During the study period, 4 patients survived, 5 patients were noted as deceased, and survival data for 2 patients remain unavailable. Patients exhibited an average survival of 7.6 (±10.4) years. The survival times within this limited patient population exhibit significant variation. Histologically, a wide spectrum of low and high-grade soft tissue and bone sarcomas were diagnosed including liposarcoma, synovial sarcoma, Ewing, osteosarcoma, or chondrosarcoma.

Conclusion: HNS are rare and challenging to treat. Surgery is the primary treatment, with postoperative radiotherapy recommended for incomplete resections or high-risk subtypes. Advanced surgical techniques and reconstruction allow for radical resections while preserving function. Incorporating genetic insights and better sarcoma classification can further optimize treatments.

咽喉部肉瘤的组织病理谱及临床处理。
简介:肉瘤是一种罕见的间质恶性肿瘤(方法:本单中心研究提供了头颈肉瘤(HNS)的综合分析,并检查了2007年至2022年在慕尼黑工业大学头颈外科治疗的患者的咽喉肉瘤的跨学科治疗方法。该研究包括年龄、性别、组织病理学诊断、治疗方式、随访和结果的数据,重点是组织病理学发现和合作治疗策略。结果:2007-2022年共发现HNS 27例。其中11例为咽部或喉部肉瘤。所有咽肉瘤均行初次切除,并根据肿瘤的位置和范围进行重建。在喉肉瘤中,3例需要喉切除术,1例半喉切除术,1例患者选择了初级放化疗而不是喉咽切除术。辅助放疗5例,放化疗3例。诊断包括一系列软组织和骨肉瘤,如脂肪肉瘤、滑膜肉瘤和骨肉瘤。在研究期间,4例患者存活,5例患者死亡,2例患者的生存数据仍无法获得。患者平均生存期为7,6(±10,4)年。在这一有限的患者群体中,生存时间表现出显著的差异。组织学上,广泛诊断为低级别和高级别软组织和骨肉瘤,包括脂肪肉瘤、滑膜肉瘤、尤文氏肉瘤、骨肉瘤或软骨肉瘤。结论:HNS罕见,治疗难度大。手术是主要的治疗方法,对于不完全切除或高危亚型推荐术后放疗。先进的外科技术和重建允许在保留功能的同时进行根治性切除。结合遗传学知识和更好的肉瘤分类可以进一步优化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oncology
Oncology 医学-肿瘤学
CiteScore
6.00
自引率
2.90%
发文量
76
审稿时长
6-12 weeks
期刊介绍: Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.
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