Epidemiologic Risk and Prevention and Interventions in Parkinson Disease: From a Nutrition-Based Perspective

IF 3.7 3区 医学 Q2 NUTRITION & DIETETICS
Fan Zhang , Yu-Xian Liu , Yun-Yue Zhu , Qiu-Yan Yu , Samwel Sylvester Msigwa , Zhi-Hai Zeng , Xiong Zhang , Hong-Mei Wu , Jian-Hong Zhu
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引用次数: 0

Abstract

Parkinson disease (PD) is a prevalent neurodegenerative disorder associated with aging. Current treatments for PD primarily focus on alleviating symptoms rather than altering the progression of the disease. The sporadic form of PD, which accounts for most cases, is thought to arise from a complex interaction between genetic predispositions and environmental factors. This review aimed to examine epidemiologic evidence regarding nutrition-related exposure factors and their associations with risk of developing PD. We proposed a tentative conclusion for each factor based on the available evidence. These associations may vary by gender and depend on dietary intake patterns and adherence. We also reviewed clinical trials on nutrition-related interventions for PD symptoms and progression. Future clinical trials may benefit from combining nutrition factors in intervention and testing within single-gender cohorts or subgroups defined by epidemiologic outcomes.
帕金森病的流行病学风险及预防和干预:基于营养的视角。
帕金森病(PD)是一种与衰老相关的普遍神经退行性疾病。目前PD的治疗主要侧重于缓解症状,而不是改变疾病的进展。散发形式的PD占大多数病例,被认为是遗传倾向和环境因素之间复杂的相互作用产生的。本综述研究了有关营养相关暴露因素及其与PD发病风险的关联的流行病学证据。我们根据现有的证据对每个因素提出了一个暂定的结论。这些关联可能因性别而异,并取决于饮食摄入模式和坚持。我们还回顾了营养相关干预PD症状和进展的临床试验。未来的临床试验可能会受益于在单性别队列或由流行病学结果定义的亚组中结合营养因素进行干预和测试。
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来源期刊
Journal of Nutrition
Journal of Nutrition 医学-营养学
CiteScore
7.60
自引率
4.80%
发文量
260
审稿时长
39 days
期刊介绍: The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.
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