Prognostic Value of Ki-67 in the Invasive Zone of Oral Squamous Cell Carcinoma

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2025-02-03 DOI:10.1111/jop.13608

Ke Li, Shuai Wang, Zihui Li, Qiuya Yu, Lingyun Liu, Fuyan Li, Lei Zhang, Guowen Sun, Yanhong Ni

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引用次数: 0

Abstract

Background

The molecular profile of cells within the tumor invasive zone, where tumor cells interact with surrounding non-tumor cells, plays a crucial role in defining tumor malignant characteristics, such as the pattern of invasion (POI). Therefore, evaluating the diagnostic value of the proliferation index molecule, Ki-67, in both tumor cells and adjacent non-tumor cells at the invasive zone with different POIs, holds significant clinical importance for oral squamous cell carcinoma (OSCC).

Methods

This retrospective study included 133 primary OSCC samples, and the spatial pattern of Ki-67 in the tumor invasive zone was analyzed by immunohistochemistry (IHC). The prognostic value of tumor cells and stroma proliferative capacity in different POIs were assessed.

Results

Ki-67 was widely expressed in tumor cells and stroma cells within the invasive zone, and cells in high-invasiveness POIs exhibit higher proliferation. Elevated Ki-67 expression in tumor cells was associated with poor overall survival (OS) and disease-free survival (DFS) in patients, which is independent of POIs. In our study, we identified the expression level of Ki-67 in tumor cells across high-invasiveness POIs as an independent risk factor for OS and DFS in OSCC patiens. Additionally, Ki-67 expression in surrounding non-tumor cells did not significantly correlate with patient survival.

Conclusion

The remarkable proliferation characteristic of tumor cells in high-invasiveness POIs of OSCC tumors plays a crucial role in the prognosis of patients.

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Ki-67在口腔鳞状细胞癌侵袭区的预后价值。

背景：肿瘤侵袭区（肿瘤细胞与周围非肿瘤细胞相互作用的区域）内细胞的分子谱在确定肿瘤的恶性特征（如侵袭模式（POI））方面起着至关重要的作用。因此，评价浸润区不同POIs的肿瘤细胞及邻近非肿瘤细胞增殖指数分子Ki-67的诊断价值，对口腔鳞癌（OSCC）具有重要的临床意义。方法：回顾性研究133例原发性OSCC，采用免疫组化（IHC）方法分析肿瘤侵袭区Ki-67的空间分布。评估不同POIs患者肿瘤细胞及间质增殖能力的预后价值。结果：Ki-67在侵袭区肿瘤细胞和间质细胞中广泛表达，高侵袭性POIs细胞具有较高的增殖能力。肿瘤细胞中Ki-67表达升高与患者总生存期（OS）和无病生存期（DFS）较差相关，与poi无关。在我们的研究中，我们确定了Ki-67在高侵袭性POIs肿瘤细胞中的表达水平是OSCC患者OS和DFS的独立危险因素。此外，Ki-67在周围非肿瘤细胞中的表达与患者生存率无显著相关性。结论：OSCC高侵袭性POIs中肿瘤细胞显著的增殖特征对患者的预后起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.