Prognostic impact of hypertension and diabetes in patients with cardiac amyloidosis

IF 3.2 2区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology Pub Date : 2025-02-01 DOI:10.1016/j.ijcard.2025.133027

Alessia Argirò , Giulia Biagioni , Carlotta Mazzoni , Mattia Zampieri , Marco Allinovi , Beatrice Musumeci , Giacomo Tini , Alessandro Cianca , Marco Merlo , Gianfranco Sinagra , Aldostefano Porcari , Marco Pozzan , Marco Canepa , Margherita Zanoletti , Marianna Eleonora Labate , Alberto Ponziani , Giulia Saturi , Irene Ruotolo , Simone Longhi , Elena Biagini , Francesco Cappelli

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引用次数: 0

Abstract

Background

Hypertension and diabetes may increase the risk of adverse events in the general population and patients with cardiomyopathies, however, their role in patients with cardiac amyloidosis (CA) is still unclarified.

Aims

to evaluate the effect on phenotype and clinical outcomes of hypertension and diabetes in patients with CA.

Methods

Data from 5 Italian Amyloidosis Referral Centres were used to describe clinical characteristics and outcomes of patients with CA based on the presence of a history of hypertension and diabetes.

Results

The study includes 887 patients with CA (311 light chain CA, 87 hereditary transthyretin CA, 489 wild-type transthyretin CA). Median age was 75 years (67–81), and 692 (78 %) were men. Five hundred-seven (57 %) patients had hypertension, 127 (14 %) had diabetes. In multivariable linear regression analysis, hypertension was associated with an increased interventricular septal thickness (coefficient 0.63,95 % CI 0.2–1.06), and augmented E/e’ ratio (1.92,95 % CI 0.55–3.29). On Cox regression, diabetes was independently associated with death and heart failure hospitalizations (HR 1.45,95 % CI 1.05–1.99, p = 0.02).

Conclusions

Patients with hypertension present a more severe phenotype with increased LV wall thickness and more severe diastolic dysfunction compared to non-hypertensive. The presence of diabetes in this cohort is associated with an increased risk of adverse outcomes.

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来源期刊

International journal of cardiology 医学-心血管系统

CiteScore

6.80

自引率

5.70%

发文量

758

审稿时长

44 days

期刊介绍： The International Journal of Cardiology is devoted to cardiology in the broadest sense. Both basic research and clinical papers can be submitted. The journal serves the interest of both practicing clinicians and researchers. In addition to original papers, we are launching a range of new manuscript types, including Consensus and Position Papers, Systematic Reviews, Meta-analyses, and Short communications. Case reports are no longer acceptable. Controversial techniques, issues on health policy and social medicine are discussed and serve as useful tools for encouraging debate.