The association between sleep duration and cognitive function in the U.S. elderly from NHANES 2011–2014: A mediation analysis for inflammatory biomarkers

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-02-01 DOI:10.1016/j.jad.2025.01.154

Meichang Wang , Xiaoli Zeng , Qifen Liu , Zilin Yang , Jingzhi Li

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引用次数: 0

Abstract

Background

Studies have shown a close association between sleep duration and cognitive function in older adults. However, no studies have explored the underlying mechanisms of this relationship. This study was designed to assess the role of inflammatory markers in the relationship between sleep duration and cognitive function in older Americans.

Methods

A total of 2502 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analysis. Cognitive function was assessed using three tests from NHANES. Sleep duration was evaluated through a self-reported sleep time questionnaire. Inflammatory biomarkers examined included leukocytes (WBC) count, neutrophil count (NE), the neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII). Mediation models were constructed to clarify the mediating role of inflammatory biomarkers.

Results

Long sleep duration (≥9 h) was associated with lower performance on CERAD (OR: -1.623; 95 % CI: −2.979 to −0.267) and DSST (OR: -3.084; 95 % CI: −5.861 to −0.308) compared to the normal sleep duration group (7–9 h). NE partially and indirectly mediated this association. Meanwhile, WBC moderated the association between long sleep duration (≥9 h) and DSST performance.

Limitations

The cross-sectional design prevents making causal inferences.

Conclusions

Long sleep duration is a risk factor for cognitive function. Inflammatory biomarkers based on blood cells present a readily accessible and cost-effective strategy for identifying sleep disorders and also significantly mediate the association between long sleep duration and cognitive function.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.