Low glucose challenge test result as a potential risk factor for delays in early child development: the Japan environment and children's study.

IF 1.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-02-01 eCollection Date: 2025-06-01 DOI:10.1007/s40200-025-01568-x

Satoshi Shinohara, Reiji Kojima, Sanae Otawa, Megumi Kushima, Kunio Miyake, Hideki Yui, Tadao Ooka, Sayaka Horiuchi, Hiroshi Yokomichi, Zentaro Yamagata, Ryoji Shinohara

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引用次数: 0

Abstract

Objectives: To clarify the relationship between maternal 50-g glucose challenge test (GCT) results and neurodevelopment in 3-year-old children and determine if low GCT results are linked to early neurodevelopmental delays in offspring.

Methods: In this nationwide prospective cohort study, we extracted data from 104,062 foetal records from the Japan Environment and Children's Study. Outcomes comprised developmental status cut-off values for the domains of the Ages and Stages Questionnaire, Third Edition. The exclusion criteria were gestational diabetes mellitus, diabetes during pregnancy, and GCT results ≥ 140 mg/dL. Based on these criteria, we included 12,472 women who had undergone a GCT between 14 and 27 weeks of gestation and divided the participants into a low-GCT group (cohort specific ≤ 10th percentile, ≤ 81 mg/dL) and a non-low-GCT group (82-139 mg/dL). Multivariable logistic regression analysis was used to investigate the association between low GCT results and early neurodevelopmental delays.

Results: Compared with infants born to women with normal GCT results, those born to women with low GCT results showed a significantly higher incidence of neurodevelopmental delays, particularly in communication, gross motor, fine motor, and problem-solving skills (adjusted odds ratio [OR] 1.35, 95% confidence interval [CI] 1.02-1.78; adjusted OR 1.31, 95% CI 1.01-1.69; adjusted OR 1.26, 95% CI 1.02-1.56; adjusted OR 1.24, 95% CI 1.01-1.54, respectively). No significant increase in the adjusted ORs (95% CIs) was observed for female offspring.

Conclusions: Low maternal GCT results are associated with offspring neurodevelopment at 3 years of age, with the association influenced by offspring sex.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-025-01568-x.

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低糖激发试验结果作为儿童早期发育迟缓的潜在危险因素：日本环境与儿童研究

目的：阐明母亲50g葡萄糖激发试验（GCT）结果与3岁儿童神经发育之间的关系，并确定低GCT结果是否与后代早期神经发育迟缓有关。方法：在这项全国前瞻性队列研究中，我们提取了来自日本环境与儿童研究的104,062例胎儿记录的数据。结果包括年龄和阶段问卷第三版领域的发展状况临界值。排除标准为妊娠期糖尿病、妊娠期糖尿病、GCT结果≥140 mg/dL。基于这些标准，我们纳入了12472名在妊娠14至27周期间接受过GCT的妇女，并将参与者分为低GCT组（队列特异性≤10百分位，≤81 mg/dL）和非低GCT组（82-139 mg/dL）。采用多变量logistic回归分析来研究低GCT结果与早期神经发育迟缓之间的关系。结果：与GCT结果正常的母亲所生的婴儿相比，GCT结果低的母亲所生的婴儿神经发育迟缓的发生率明显更高，特别是在沟通、大肌肉运动、精细运动和解决问题的能力方面(调整优势比[OR] 1.35, 95%可信区间[CI] 1.02-1.78；调整OR 1.31, 95% CI 1.01-1.69；调整OR 1.26, 95% CI 1.02-1.56；调整OR 1.24, 95% CI 1.01-1.54)。雌性后代调整后的ORs （95% ci）没有显著增加。结论：低母体GCT结果与后代3岁时的神经发育有关，且受后代性别影响。补充资料：在线版本包含补充资料，网址为10.1007/s40200-025-01568-x。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.