Assessment of sarcopenic obesity in patients with acromegaly.

IF 3.3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pituitary Pub Date : 2025-02-03 DOI:10.1007/s11102-024-01494-w

Claudia Pinheiro Sanches Rocha, Natália Nachbar Hupalowski, Vicente Florentino Castaldo Andrade, Cesar Luiz Boguszewski, Victória Zeghbi Cochenski Borba

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引用次数: 0

Abstract

Purpose: Sarcopenic obesity (SO), a condition characterized by the coexistence of obesity and sarcopenia, has primarily been studied in elderly populations. However, it can also affect individuals with chronic diseases. This study aims to evaluate the prevalence of SO in patients with acromegaly.

Methods: Observational, cross-sectional study, involving patients with acromegaly followed at a tertiary center and controls matched for age and sex. Health assessment questionnaire, physical tests, body composition and bone mineral density assessment, were performed in all participants. SO was diagnosed using criteria from ESPEN and EASO Consensus Statements.

Results: 48 patients with acromegaly (acromegaly group - AG, 26 women, mean age 56.3 ± 11.6, mean BMI 31.3 ± 4.9) were compared to 48 controls (control group - CG, 26 women, mean age 56.7 ± 13.7, BMI 25.5 ± 4.7). Despite having greater total and appendicular lean mass, AG showed significant impairments in physical performance, particularly in strength, gait speed and balance (p < 0.05). The prevalence of SO in the AG was 16.7%, compared to 0% in the CG (p = 0.006), and positively correlated with increased fat mass and impaired physical performance.

Conclusions: SO is present in patients with acromegaly and is associated with notable functional impairments despite increased muscle mass.

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评估肢端肥大症患者的肌肉松弛性肥胖。

目的：肌少性肥胖（SO）是一种以肥胖和肌少症共存为特征的疾病，主要研究对象是老年人群。然而，它也会影响患有慢性疾病的人。本研究旨在评估肢端肥大症患者中SO的患病率。方法：观察性横断面研究，纳入在三级中心随访的肢端肥大症患者和年龄和性别匹配的对照组。对所有参与者进行健康评估问卷、体格测试、身体成分和骨密度评估。根据ESPEN和EASO共识声明的标准诊断SO。结果：将48例肢端肥大患者（肢端肥大组- AG， 26例女性，平均年龄56.3±11.6，平均BMI 31.3±4.9）与48例对照组（对照组- CG， 26例女性，平均年龄56.7±13.7,BMI 25.5±4.7）进行比较。尽管有更大的总瘦质量和阑尾瘦质量，但AG在身体表现方面表现出明显的损伤，特别是在力量、步态速度和平衡方面(p结论：SO存在于肢端肥大症患者中，尽管肌肉质量增加，但仍与显著的功能损伤相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pituitary 医学-内分泌学与代谢

CiteScore

7.10

自引率

7.90%

发文量

审稿时长

6 months

期刊介绍： Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.