Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances

IF 3.5 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2024-12-29 DOI:10.1002/ejp.4765

Katarina Rukavina, Juliet Staunton, Pavlos Zinzalias, Magdalena Krbot Skoric, Karolina Poplawska-Domaszewicz, Antonio Pisani, Kirsty Bannister, K Ray Chaudhuri

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引用次数: 0

Abstract

Background

Parkinson's disease (PD) is the second most common neurodegenerative disease. Over two thirds of People with Parkinson's (PwP) live with chronic PD-related pain, but its successful management remains an unmet need. Unrevealing links between pain and other motor and non-motor symptoms (NMS) of PD may accelerate delivery of much needed precision pain medicine approaches for PwP.

Methods

An exploratory, cross-sectional analysis of the prospective, observational, multicentre, international study ‘The Non-motor International Longitudinal, Real-Life Study in PD - NILS’.

Results

In 109 PwP (41.3% women, age 64.29 ± 9.80 years, disease duration 5.50 (2.44–10.89) years, H&Y stage 2 (1–4), levodopa equivalent daily dose 575.00 (315.00–1004.00) mg), strong correlations were noted between the total burden of PD-related pain and the total NMS burden (r_s = 0.641) and moderate with disturbances of sleep/fatigue (r_s = 0.483), cognitive issues (r_s = 0.445), motor complications (r_s = 0.421), anxiety (r_s = 0.441) and depression (r_s = 0.451). In a multivariate linear regression analysis, motor complications (B = 2.063, 95% CI for B 1.152–2.974, p < 0.001), sleep disturbances/fatigue (B = 0.392, 95% CI for B 0.064–0.720, p = 0.020) and anxiety (B = 0.912, 95% CI for B 0.165–1.659, p = 0.017) significantly impacted the overall burden of pain.

Conclusions

In PwP, PD-related pain is significantly impacted by motor complications, anxiety and sleep disturbances. A personalized, tailored approach to management of pain in PwP need to accurately identify and tackle all its interrelated symptoms. Whether successful management of motor complications, anxiety and sleep disturbances may contribute to pain relief in PwP for specified cohorts needs to be a focus of future randomized controlled clinical trials.

Significance statement

This explorative analysis identifies the frequent overlap of chronic pain, motor complications, sleep disturbances and anxiety in Parkinson's disease and could help advance the development of precise and effective pain management strategies tailored to the needs of People with Parkinson's.

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.