Site Specific C3‐Alkenylation of Indoles Mediated by In Situ C−H Iodination

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-01-01 DOI:10.1002/ajoc.202400599

Yongli Zhao , Dingsheng Cao , Prof. Dr. Jie‐Ping Wan , Yunyun Liu

引用次数: 0

Abstract

The C3‐alkenylation of indoles have been developed by means of a novel in situ iodination tactic which is capable of mediating the Heck coupling with alkenes. The method features specific site‐selectivity oriented by the C−I bond, high‐step efficiency without pre‐functionalization for C‐halogen bond construction, as well as the highly general tolerance to different terminal alkenes, including unactivated alkenes, acrylates, acrylic acid, vinyl sulfone as well as different vinyl functionalized natural products.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.