Integrated Antigenic and Nucleic Acid Detection in Single Virions and Extracellular Vesicles with Viral Content (Adv. Healthcare Mater. 3/2025)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-01-27 DOI:10.1002/adhm.202570018

Kim Truc Nguyen, Xilal Y. Rima, Luong T. H. Nguyen, Xinyu Wang, Kwang Joo Kwak, Min Jin Yoon, Hong Li, Chi-Ling Chiang, Jacob Doon-Ralls, Kelsey Scherler, Shannon Fallen, Stephanie L. Godfrey, Julie A. Wallick, Setty M. Magaña, Andre F. Palmer, Inyoul Lee, Christopher C. Nunn, Kimberly M. Reeves, Henry G. Kaplan, Jason D. Goldman, James R. Heath, Kai Wang, Preeti Pancholi, L. James Lee, Eduardo Reátegui

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Abstract

Biochip Antigen and RNA Assay

The Biochip Antigen and RNA Assay (BARA) enables the simultaneous detection of nucleic acids and antigens by integrating immunofluorescence and fluorescent in situ hybridization at a single-particle resolution. The BARA thus enables the highly sensitive quantification of virions in complex biofluids and continued monitoring of viral content in extracellular vesicles. Overall, the BARA offers an unmatched perspective into virion-mediated outbreaks. More details can be found in article 2400622 by Eduardo Reátegui and co-workers.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.