Long-term survival outcomes in young-onset colorectal cancer: A population-based cohort study

IF 2.9 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Colorectal Disease Pub Date : 2025-01-26 DOI:10.1111/codi.70007

Amy M. Y. Cao, Michael L. R. Lonne, David A. Clark

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引用次数: 0

Abstract

Aim

Long-term survival outcomes in young-onset colorectal cancer patients are contradictory and inconsistent. Some studies report overall survival to be significantly superior compared with older adults, while others report worse survival. Worldwide, the incidence of young-onset colorectal cancer has, alarmingly, nearly doubled since the 1990s, in stark contrast to that in those over 50 years of age. Long-term survival in young-onset colorectal cancer has not been explored in the Australian population. The aim of this study was to investigate cancer-specific and overall survival up to 10 years.

Method

This was a retrospective population-based cohort study. All colorectal cancer diagnoses between 2001 and 2020 in the state of Queensland, Australia were reviewed. Young-onset colorectal cancer (20–49 years) was compared with late-onset colorectal cancer (50 years+).

Results

There were 52 697 adults diagnosed with colorectal cancer in Queensland. Young-onset colorectal cancer accounted for 7.7% of these. Young-onset colorectal cancer had a greater proportion of Stage III and IV disease than the late-onset group (66% vs. 59%, p < 0.001). Despite this, young-onset colorectal cancer had statistically significant improved overall survival at all time points to 10 years (p < 0.001). Stage-for-stage cancer-specific survival to 10 years was superior in all stages in young-onset colorectal cancer (p < 0.001).

Conclusion

Both stage-for-stage cancer-specific and overall survival were superior in young-onset colorectal cancer compared with those aged 50 years and above, up to 10 years.

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来源期刊

Colorectal Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

11.80%

发文量

406

审稿时长

1.5 months

期刊介绍： Diseases of the colon and rectum are common and offer a number of exciting challenges. Clinical, diagnostic and basic science research is expanding rapidly. There is increasing demand from purchasers of health care and patients for clinicians to keep abreast of the latest research and developments, and to translate these into routine practice. Technological advances in diagnosis, surgical technique, new pharmaceuticals, molecular genetics and other basic sciences have transformed many aspects of how these diseases are managed. Such progress will accelerate. Colorectal Disease offers a real benefit to subscribers and authors. It is first and foremost a vehicle for publishing original research relating to the demanding, rapidly expanding field of colorectal diseases. Essential for surgeons, pathologists, oncologists, gastroenterologists and health professionals caring for patients with a disease of the lower GI tract, Colorectal Disease furthers education and inter-professional development by including regular review articles and discussions of current controversies. Note that the journal does not usually accept paediatric surgical papers.