Genome-wide association studies on body weight in Loumen ducks

IF 1.8 3区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal genetics Pub Date : 2025-01-26 DOI:10.1111/age.13503

Hongxiang Liu, Yifei Wang, Chunhong Zhu, Zhicheng Wang, Weitao Song, Wenjuan Xu, Zhiyun Tao, Shuangjie Zhang, Huifang Li, Honglin Liu

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Abstract

Body weight is an important trait associated with meat production in the poultry industry. To better understand the genetic basis of body weights in ducks, we estimated genetic parameters and performed a genome-wide association study. The phenotypic values of body weights at ages 0 weeks (bw0) and 8 weeks (bw8) were collected individually from 199 Loumen ducks, and their genotypes were assayed with whole genome re-sequencing. The heritability of bw0 and bw8 are 0.32 and 0.43, respectively, and the genetic correlation of bw0 and bw8 was very low (−7.256e-5). The genome-wide association study results identified eight SNPs significantly associated with bw0 and bw8. The two and nine genes nearest to the significant SNPs were selected as candidate genes: PIK3R5 and MYH10 for bw0, and LOC119717016, RHOJ, PPP2R5E, BRF1, LOC106018961, NUDT14, JAG2, CEP170B, and AKT1 for bw8. Together, the SNPs and candidate genes identified in this study advance understanding of the complex genetic architecture of bw0 and bw8, and provide important clues for future implementation of a genomic selection program in Loumen ducks.

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娄门鸭体重的全基因组关联研究

在家禽业中，体重是与肉类生产相关的一个重要性状。为了更好地了解鸭子体重的遗传基础，我们估计了遗传参数并进行了全基因组关联研究。分别采集199只娄门鸭0周龄和8周龄体重表型值，采用全基因组重测序法测定基因型。bw0和bw8的遗传力分别为0.32和0.43，遗传相关性极低（- 7.256e-5）。全基因组关联研究结果确定了8个与bw0和bw8显著相关的snp。选择最接近显著snp的2个和9个基因作为候选基因：bw0的PIK3R5和MYH10， bw8的LOC119717016、RHOJ、PPP2R5E、BRF1、LOC106018961、NUDT14、JAG2、CEP170B和AKT1。总之，本研究中发现的SNPs和候选基因促进了对bw0和bw8复杂遗传结构的理解，并为未来娄门鸭基因组选择计划的实施提供了重要线索。

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来源期刊

Animal genetics 生物-奶制品与动物科学

CiteScore

4.60

自引率

4.20%

发文量

115

审稿时长

5 months

期刊介绍： Animal Genetics reports frontline research on immunogenetics, molecular genetics and functional genomics of economically important and domesticated animals. Publications include the study of variability at gene and protein levels, mapping of genes, traits and QTLs, associations between genes and traits, genetic diversity, and characterization of gene or protein expression and control related to phenotypic or genetic variation. The journal publishes full-length articles, short communications and brief notes, as well as commissioned and submitted mini-reviews on issues of interest to Animal Genetics readers.