Novel Use of Magnesium Hydride to Prevent Peritoneal Adhesions by Regulating Inflammation and Oxidative Stress

Abstract

Peritoneal adhesions (PAs) represent a significant clinical challenge, primarily arising from excessive post-surgical inflammation, which leads to the deposition of fibrin and extracellular matrix, forming adhesive bands that can cause severe complications such as intestinal obstruction and infertility. Current therapeutic options offer limited efficacy in preventing or treating PAs, highlighting the need for new strategies. To address this issue, magnesium hydride (MgH₂) microparticles capable are developed of stable hydrogen (H₂) storage and controlled release to regulate inflammation and promote tissue regeneration. The antioxidant properties, inflammation modulation, and H₂ release profile of MgH₂ are evaluated in vitro, while its anti-adhesion, angiogenic, and regenerative effects are assessed in vivo using postoperative rat models. These findings demonstrate that MgH₂ significantly mitigates inflammatory dysregulation, reduces oxidative stress, and effectively prevents peritoneal adhesion formation at wound sites. These results suggest that MgH₂ offers a promising therapeutic approach for preventing PAs and supporting beneficial tissue regeneration, presenting a potential clinical solution for postoperative adhesion management.