Yasmin M. Ahmed, Sami A. Al-Hussain, Magdi E. A. Zaki, Gehad G. Mohamed
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引用次数: 0
Abstract
Reaction of Organotin (IV) salts with tridentate Schiff bases (SBI and SBII) reacted in 1:1 M ratios where complexes (1–6) were afforded. Organotin (IV) complexes with the formula [Sn (CH3)2(SBI)ClH2O]Cl (1), [Sn(C4H9)2(SBI)Cl2]H2O (2), [Sn(C6H5)4(SBI)] (3), [Sn (CH3)2(SBII)Cl2]3H2O (4), [Sn(C4H9)2(SBII)Cl2]2H2O (5) and [Sn(C6H5)4(SBII)]H2O (6) (SBI = 2(E)-2-(((3-hydroxyphenyl)imino)methyl)phenol and SBII = (E)-2-(((3-aminophenyl)imino)-methyl)phenol were described. Every Tin (IV) complex (1–6) had a distinct color and was soluble in DMF and DMSO organic solvents. The complexes have all been thoroughly examined using mass spectrum analysis, FT-IR, UV–vis, 1H-NMR, and CHN investigations. For both SBI and SBII, the Schiff bases chelated to the tin metal ion in a tridentate fashion through NOO and NNO atoms, including nitrogen atoms of the azomethine group. This was demonstrated by the spectroscopic data of the ligand and its related complexes (1–6). The tin atom was found to have pentagonal-bipyramidal geometry according to elemental analyses data coupled with electronic spectral data. The complexes were nonelectrolytes except Complex 1 is electrolyte. The complexes (1–6) thermal deterioration occurred between 200°C and 800°C, according to thermogravimetric analysis performed during thermal decomposition under nitrogen. The in vitro tests measured the efficacy of the Schiff base Tin (IV) complexes (1–6) to inhibit the growth of several types of bacteria and fungi. When compared to the Schiff bases ligand, it was shown that the complexes were more successful in killing bacteria and fungi organisms. In order to interpret the compounds' structure and reactivity, density functional calculations were done. Molecular docking by the protein locations of 2V5Z and 7KGW was utilized to evaluate possible medicines using MOE 2008. Without verifying results with MD simulations, the work was designed to explore molecular docking.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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