A Facile Route Through Iodine-Mediated Synthesis of Isoxazole Derivatives from Chalcone Epoxide

Abstract

A novel synthetic route for the direct synthesis of 4,5-diarylisoxazoles is less common. A facile and efficient synthesis of 4,5-diarylisoxazole derivatives via I₂-mediated reaction from α,β-chalcone epoxides under mild and metal-free conditions is developed. This protocol enables facile access to 4,5-diarylisoxazole derivatives in good to excellent yields using EtOH/H₂O (1:1) solvent at 80 °C temperature. The structural integrity of the compounds was confirmed by ¹H, ¹³C, IR, CHNS, GC-MS, and SC-XRD analysis.