Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2024-11-21 DOI:10.1002/cjoc.202400697

Yi Zang, Ruo-nan Sun, Ran-qi Feng, Hong-hui Zhu, Xu-wen Li

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Abstract

Terpenoids are a large and diverse family of secondary metabolites that have gained more attention from chemists and pharmacologists for their intriguing skeletons and broad biological activities, including anti-inflammatory, antitumoral, antimicrobial, and anti-viral effects. Based on the previous reviews, this review comprehensively summarized recent advances on bioactive terpenoids, focusing on their intriguing structural features and promising biological activities, covering literature from 2020 to 2023. In this review, 532 terpenoids with remarkable chemical architectures and biological properties are classified into sesquiterpenoids (142), diterpenoids (129), sesterterpenoids (24), triterpenoids (52), and meroterpenoids (185), that were isolated from terrestrial and marine resources. This review would provide a reference for researchers to rapidly discover the interesting terpenoids for further study as promising drug leads.

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具有有趣化学骨架和生物活性的萜类化合物的最新进展

萜类化合物是一个庞大而多样的次生代谢物家族，因其有趣的骨架和广泛的生物活性，包括抗炎、抗肿瘤、抗菌和抗病毒作用，而受到化学家和药理学家的更多关注。本文在综述的基础上，综合总结了生物活性萜类化合物的研究进展，重点介绍了其有趣的结构特征和具有前景的生物活性，涵盖了2020年至2023年的文献。本文综述了532种从陆地和海洋资源中分离得到的具有显著化学结构和生物学特性的萜类化合物，将其分类为倍半萜类（142）、二萜类（129）、酯萜类（24）、三萜类（52）和巯基萜类（185）。这一综述将为研究人员快速发现感兴趣的萜类化合物作为有前景的药物线索进行进一步研究提供参考。

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.