{"title":"Cover Feature: Platinum Stabilises a Molten-Globule Conformation of a Small Globular Cytosolic Protein SUMO1 (Chem. Asian J. 2/2025)","authors":"Suman Tiwari, Sri Rama Koti Ainavarapu","doi":"10.1002/asia.202580202","DOIUrl":null,"url":null,"abstract":"<p>This illustration highlights how metal binding can alter protein structure. SUMO1, a small globular protein, forms a molten globule state upon binding with platinum. The Pt ions, shown as fiery nodes, indicate the energy and disruption introduced at specific sites in the protein. As Pt binds, SUMO1′s fold softens, transitioning into a “molten globule” state – partially unfolded, more flexible, yet retaining some structural elements. This visual underscores the dynamic nature of protein shapes in response to external metal ion interactions. More details can be found in article e202400971 by Suman Tiwari and Sri Rama Koti Ainavarapu.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 2","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202580202","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry - An Asian Journal","FirstCategoryId":"1","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/asia.202580202","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
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Abstract
This illustration highlights how metal binding can alter protein structure. SUMO1, a small globular protein, forms a molten globule state upon binding with platinum. The Pt ions, shown as fiery nodes, indicate the energy and disruption introduced at specific sites in the protein. As Pt binds, SUMO1′s fold softens, transitioning into a “molten globule” state – partially unfolded, more flexible, yet retaining some structural elements. This visual underscores the dynamic nature of protein shapes in response to external metal ion interactions. More details can be found in article e202400971 by Suman Tiwari and Sri Rama Koti Ainavarapu.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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