Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method

IF 4.2 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Elahe Abdollahi, Vahid Haddadi-Asl, Hanie Ahmadi, Mastoure Shirjandi, Fatemeh Khanipour
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Abstract

Development of smart drug delivery systems (DDSs) for effective delivering drugs to targeted areas and achieving controlled drug release (CDR) is critical for cancer chemotherapy. The purpose of this study is synthesis of polydopamine (PDA) nanocapsules and analyze the adsorption and release properties of doxorubicin (DOX). PDA nanocapsules are manufactured using hard template approach. The influence of various parameters such as pH, adsorption time, and initial DOX content on the adsorption and release process is investigated. The resulting adsorption isotherm is consistent with the Langmuir isotherm, indicating that DOX adsorption on PDA nanocapsules is homogenous, uniform, and monolayer. PDA nanocapsules have an adsorption capacity of 689.6 mg g−1 under alkaline conditions, which is attributed to phenol group deprotonation mechanism and electrostatic repulsion. The adsorption kinetics are more consistent with the pseudo-second-order model. Furthermore, raising initial concentration of DOX results in a greatly increased adsorption capacity due to a larger driving force. Among the several parameters that can influence the pace and degree of DOX loading and release, local pH is regarded as a significant environmental component in the processes. Thus, pH-responsive PDA nanocapsules have a significant potential for usage in locations with aberrant pH level, such as cancer tissue.

Abstract Image

硬模板法制备聚多巴胺纳米胶囊DOX释放动力学研究
开发智能给药系统(dds)以有效地将药物递送到靶向区域并实现药物控制释放(CDR)是癌症化疗的关键。本研究的目的是合成聚多巴胺(PDA)纳米胶囊,并对多柔比星(DOX)的吸附和释放特性进行分析。采用硬模板法制备PDA纳米胶囊。考察了pH、吸附时间、初始DOX含量等参数对吸附和释放过程的影响。所得吸附等温线与Langmuir等温线一致,表明DOX在PDA纳米胶囊上的吸附是均匀的、均匀的、单层的。在碱性条件下,PDA纳米胶囊的吸附量为689.6 mg g−1,这主要归因于苯酚基去质子化机理和静电斥力。吸附动力学更符合准二阶模型。此外,提高DOX的初始浓度,由于驱动力更大,吸附量大大增加。在影响DOX加载和释放速度和程度的几个参数中,局部pH被认为是该过程中的一个重要环境成分。因此,pH响应PDA纳米胶囊在pH值异常的部位(如癌症组织)具有巨大的应用潜力。
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来源期刊
Macromolecular Materials and Engineering
Macromolecular Materials and Engineering 工程技术-材料科学:综合
CiteScore
7.30
自引率
5.10%
发文量
328
审稿时长
1.6 months
期刊介绍: Macromolecular Materials and Engineering is the high-quality polymer science journal dedicated to the design, modification, characterization, processing and application of advanced polymeric materials, including membranes, sensors, sustainability, composites, fibers, foams, 3D printing, actuators as well as energy and electronic applications. Macromolecular Materials and Engineering is among the top journals publishing original research in polymer science. The journal presents strictly peer-reviewed Research Articles, Reviews, Perspectives and Comments. ISSN: 1438-7492 (print). 1439-2054 (online). Readership:Polymer scientists, chemists, physicists, materials scientists, engineers Abstracting and Indexing Information: CAS: Chemical Abstracts Service (ACS) CCR Database (Clarivate Analytics) Chemical Abstracts Service/SciFinder (ACS) Chemistry Server Reaction Center (Clarivate Analytics) ChemWeb (ChemIndustry.com) Chimica Database (Elsevier) COMPENDEX (Elsevier) Current Contents: Physical, Chemical & Earth Sciences (Clarivate Analytics) Directory of Open Access Journals (DOAJ) INSPEC (IET) Journal Citation Reports/Science Edition (Clarivate Analytics) Materials Science & Engineering Database (ProQuest) PASCAL Database (INIST/CNRS) Polymer Library (iSmithers RAPRA) Reaction Citation Index (Clarivate Analytics) Science Citation Index (Clarivate Analytics) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) SCOPUS (Elsevier) Technology Collection (ProQuest) Web of Science (Clarivate Analytics)
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