Site‐Selective Acylation of Vinylcyclopropanes under Visible‐Light Photocatalysis

Abstract

We herein disclose a protocol for linear‐selective ring‐opening acylation of a range of electron‐poor VCPs with α‐ketoacids by Ir‐photocatalyst. While electron‐poor VCPs could be sensitized with various radical species generated under different reaction conditions including photo‐redox processes, exploring similar repertoire with acyl radical remains unexplored. Since the linear selective ring opening leads to translocation of the vinylic olefin into an internal one, terminal addition of VCP systems with electronically diverse groups present at the terminus, permitting formation of tailored of building blocks.