Synthesis and Structural Characterization of Four Bidentate Ortho-Hydroxy Schiff Bases and Their Copper (II) Complexes: Evaluation of Biological Activities, Antioxidant Power, and Molecular Docking Studies

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-01-12 DOI:10.1002/aoc.7954

Sadia Boukreris, Narimane Kheddam, Mohammed Hadj Youcef, Nisserine Hamini-Kadar, Tayeb Benabdallah

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Abstract

Four ortho-hydroxy aromatic bidentate Schiff bases were synthesized along with the corresponding copper (II) complexes and characterized by various analytical methods. The spatial configurations of the metal complexes were suggested in light of the analytical results obtained. Antibacterial evaluations revealed that the ligands were more active than their Cu(II) complexes. The study of antifungal activity showed that the fungus Candida albicans was more inhibited by the ligands (HL₃ and HL₄) and their Cu(II) complexes (IZ = 25 mm). According to the evaluation of antioxidant potency by the DPPH method, only ligand HL₄ demonstrated a comparatively low ability to scavenge free radicals compared to the ascorbic acid reference. Using the AutoDock 4.2 program, molecular docking investigations were conducted with the aim of predicting the structure–activity relationship for antibacterial qualities. Using the active sites of receptor proteins, the synthesized ligands were evaluated by molecular docking assays. A good correlation was found between the results of experimental antibacterial activity and the molecular docking data.

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.