Rapid Whole-Organ Characterization via Quantitative Light-Sheet Microscopy (Laser Photonics Rev. 19(3)/2025)

Abstract

Whole-Organ Imaging

A quantitative light-sheet microscopy platform has been developed to enable highly time-efficient assessments of fibrous structures within the cleared whole organ. This platform achieves automatic identification of medulla and cortex within the mouse ovary, and leads to a better understanding of the immune microenvironment by obtaining heterogeneous distributions of immune cells. See article 2401177 by Min Guo, Zhiyi Liu, and co-workers for more details.