Garam Kim, So-Jeong Kim, Jung-Hyeuk Kim, Yong-Kwan Kim, Weon-Hwa Jheong
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引用次数: 0
Abstract
The African swine fever virus (ASFV) causes African swine fever (ASF), a highly lethal disease affecting domestic pigs and wild boars. Since its initial outbreak in October 2019 in Yeoncheon, Gyeonggi Province, ASF has continued to spread in South Korea. This study aimed to differentiate closely related ASFV strains through the analysis of the intergenic region (IGR) between I73R and I329L genes. In 2019, genetic analysis confirmed one IGR I type case and two IGR III type cases in Paju, followed by two more IGR III type cases in 2020. After a period of detecting only the IGR II type, IGR III type cases re-emerged in Pohang and Cheong-song in November and December 2023. Genetic analysis using B646L, CP204, B602L, and EP402R genes confirmed that the IGR III strains belong to genotype II and serogroup 8, similar to the Georgia/2007/1 strain but differing in IGR type. Since the first occurrence of ASF in wild boars in South Korea, we have continuously monitored the introduction and variation of ASFV. As a result, we reconfirmed the presence of the IGR III type ASFV in 2023, 3 years and 8 months later, in a different area from where it was last detected. This finding would not have been possible without the continuous monitoring of ASFV introduction and genetic variation. We emphasize the critical role of regular monitoring based on molecular markers and comprehensive genomic analysis in enhancing the effectiveness of ASFV control and prevention.
期刊介绍：
Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions):
Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread.
Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope.
Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies.
Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies).
Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.
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