Association Between TyG-BMI Index and Hyperuricemia in Adult Women

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Endocrinology, Diabetes and Metabolism Pub Date : 2025-02-03 DOI:10.1002/edm2.70028

Kelibinuer Mutailipu, Junwei Guo, Jiajing Yin, Yue Wang, Liesheng Lu, Xuyang Jia, Jie Zhang, Shen Qu, Haibing Chen, Le Bu

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Abstract

Purpose

This study aimed to explore the relationship between hyperuricemia (HUA), the triglyceride-glucose index (TyG) and its derivatives in adult women.

Methods

A cross-sectional analysis was conducted on 1105 female patients from Shanghai Tenth People's Hospital. Participants were divided into HUA (n = 331) and non-HUA (n = 774) groups. Clinical and laboratory data were collected, and indices such as body mass index (BMI), TyG and TyG-BMI were calculated. Statistical analyses included univariate and multivariate logistic regression and receiver operating characteristic (ROC) curve analysis.

Results

The HUA group showed higher BMI, blood pressure and metabolic parameters. TyG, TyG-BMI and BMI were positively correlated with uric acid levels. ROC analysis revealed that TyG-BMI (AUC = 0.877) had better predictive power for HUA than TyG (AUC = 0.829) or BMI (AUC = 0.867). Multivariate analysis showed TyG-BMI and BMI as independent predictors, with women in the highest quartiles having a 3.111-fold and 2.779-fold higher risk for HUA, respectively.

Conclusion

TyG-BMI is the most effective predictor of HUA in women, surpassing TyG and BMI alone. It offers a practical tool for early identification and intervention in women at risk of HUA.

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成年女性TyG-BMI指数与高尿酸血症的关系

目的探讨成年女性高尿酸血症（HUA）与甘油三酯-葡萄糖指数（TyG）及其衍生物之间的关系。方法对上海市第十人民医院1105例女性患者进行横断面分析。参与者被分为HUA组（n = 331）和非HUA组（n = 774）。收集临床及实验室资料，计算体重指数（BMI）、TyG及TyG-BMI等指标。统计分析包括单因素和多因素logistic回归及受试者工作特征（ROC）曲线分析。结果HUA组患者BMI、血压、代谢指标均高于对照组。TyG、TyG-BMI、BMI与尿酸水平呈正相关。ROC分析显示，TyG-BMI （AUC = 0.877）对HUA的预测能力优于TyG （AUC = 0.829）或BMI （AUC = 0.867）。多变量分析显示，TyG-BMI和BMI是独立预测因子，最高四分位数的女性HUA风险分别高出3.111倍和2.779倍。结论TyG-BMI是女性HUA最有效的预测因子，优于单独的TyG和BMI。它为早期识别和干预有HUA风险的妇女提供了一个实用的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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