{"title":"pH-Sensitive Amphiphilic Block Copolymer for Kaempferol Delivery in Controlled Drug Release Therapy for Chronic Obstructive Pulmonary Disease","authors":"Y. Cao, Y.-M. Lu","doi":"10.1134/S1070363224120272","DOIUrl":null,"url":null,"abstract":"<p>Chronic obstructive pulmonary disease (COPD) is a common pulmonary disorder with high morbidity, often leading to complications like pulmonary hypertension. Kaempferol, with its antioxidant and anti-inflammatory properties, shows promise in improving COPD outcomes. In this study, we developed a pH-sensitive fluorescent polymer, PAAS-DIA-SDOO, to load 4-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid methyl ester and kaempferol, forming the nanocomposite PAAS-DIA-SDOO@<b>1</b>@Kaempferol. This nanocomposite demonstrated high drug-loading capacity and allowed real-time monitoring of drug release. In COPD model cells, it significantly enhanced cell proliferation and reduced inflammation, highlighting its potential as a smart drug delivery system for targeted COPD treatment. This innovation offers promising therapeutic improvements by enhancing drug efficacy and reducing side effects.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3363 - 3371"},"PeriodicalIF":0.9000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363224120272","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Chronic obstructive pulmonary disease (COPD) is a common pulmonary disorder with high morbidity, often leading to complications like pulmonary hypertension. Kaempferol, with its antioxidant and anti-inflammatory properties, shows promise in improving COPD outcomes. In this study, we developed a pH-sensitive fluorescent polymer, PAAS-DIA-SDOO, to load 4-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid methyl ester and kaempferol, forming the nanocomposite PAAS-DIA-SDOO@1@Kaempferol. This nanocomposite demonstrated high drug-loading capacity and allowed real-time monitoring of drug release. In COPD model cells, it significantly enhanced cell proliferation and reduced inflammation, highlighting its potential as a smart drug delivery system for targeted COPD treatment. This innovation offers promising therapeutic improvements by enhancing drug efficacy and reducing side effects.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
