Synthesis and Properties of New Water-Soluble Derivatives of Polyfunctional Pillar[5]arenes Containing Terminal Ammonium Groups

Abstract

New water-soluble derivatives of polyfunctional pillar[5]arenes containing ammonium substituents were synthesized. It was shown that these compounds are capable of condensing an oligonucleotide to form transparent droplets in an aqueous solution via the liquid–liquid phase separation mechanism, which was confirmed by ¹H NMR spectroscopy and optical microscopy. The resulting oligonucleotide–pillar[5]aren systems can be useful for creating model structures of membraneless organelles intended to study their biophysical properties.