Mechanistic Analysis of Porous Iron Scaffold Degradation in Cancellous Bone Structure Subjected to Dynamic Simulated Body Fluid

Abstract

This work examines the impact of incorporating the physiological conditions of human cancellous bone, by integrating similar porosity of porous Fe with the cancellous bone under dynamic immersion test. All of the porous Fe specimens with ~ 80% porosity were immersed in Simulated Body Fluid (SBF) with a flow rate of 0.3 ml/min integrated with cancellous bone for 7, 14 and 28 days. Porous Fe with the lowest surface area has the highest degradation rate despite having the lowest relative weight loss. The relationship between fluid induced shear stress and weight loss of specimens have been established.